Panic-Induced Elevation of Plasma MHPG Levels in Phobic-Anxious Patients: Effects of Clonidine and Imipramine
Ko G, Elsworth J, Roth R, Rifkin B, Leigh H, Redmond D. Panic-Induced Elevation of Plasma MHPG Levels in Phobic-Anxious Patients: Effects of Clonidine and Imipramine. JAMA Psychiatry 1983, 40: 425-430. PMID: 6838322, DOI: 10.1001/archpsyc.1983.01790040079011.Peer-Reviewed Original ResearchConceptsPlasma MHPG levelsMHPG levelsEffects of clonidineSignificant symptom reductionPlasma MHPG concentrationSelf-rated anxietyPlacebo treatmentCrossover trialMHPG concentrationsPlasma levelsNoradrenergic activityDrug treatmentDrug trialsSymptom reductionDiminished suppressionPanic attacksPanic symptomsImipramine hydrochlorideClonidinePatientsPhobic stimuliImipramineTrialsAnxietyTreatment