Divergent effects of putative anxiolytics on stress‐induced Fos expression in the mesoprefrontal system of the rat
Morrow B, Elsworth J, Lee E, Roth R. Divergent effects of putative anxiolytics on stress‐induced Fos expression in the mesoprefrontal system of the rat. Synapse 2000, 36: 143-154. PMID: 10767061, DOI: 10.1002/(sici)1098-2396(200005)36:2<143::aid-syn7>3.0.co;2-h.Peer-Reviewed Original ResearchConceptsVentral tegmental areaFos-LITegmental areaMedial prefrontal cortexPutative anxiolyticsBenzodiazepine agonistsStress-induced Fos-like immunoreactivityPartial agonistStress-induced Fos expressionGlycine/NMDA receptorPrefrontal cortexMesoprefrontal dopamine neuronsPutative anxiolytic agentsTH-LI cellsSaline-treated ratsFos-like immunoreactivityAnxiolytic-like actionFos-LI nucleiWeak partial agonistStress-induced increaseFear-inducing behaviorFootshock paradigmAlpha2 agonistsStress-induced activationDopaminergic neurons