1983
Panic-Induced Elevation of Plasma MHPG Levels in Phobic-Anxious Patients: Effects of Clonidine and Imipramine
Ko G, Elsworth J, Roth R, Rifkin B, Leigh H, Redmond D. Panic-Induced Elevation of Plasma MHPG Levels in Phobic-Anxious Patients: Effects of Clonidine and Imipramine. JAMA Psychiatry 1983, 40: 425-430. PMID: 6838322, DOI: 10.1001/archpsyc.1983.01790040079011.Peer-Reviewed Original ResearchConceptsPlasma MHPG levelsMHPG levelsEffects of clonidineSignificant symptom reductionPlasma MHPG concentrationSelf-rated anxietyPlacebo treatmentCrossover trialMHPG concentrationsPlasma levelsNoradrenergic activityDrug treatmentDrug trialsSymptom reductionDiminished suppressionPanic attacksPanic symptomsImipramine hydrochlorideClonidinePatientsPhobic stimuliImipramineTrialsAnxietyTreatment
1982
Brain catecholamine metabolites and behavior in morphine withdrawal
Swann A, Elsworth J, Charney D, Jablons D, Roth R, Redmond D, Maas J. Brain catecholamine metabolites and behavior in morphine withdrawal. European Journal Of Pharmacology 1982, 86: 167-175. PMID: 6297931, DOI: 10.1016/0014-2999(82)90314-4.Peer-Reviewed Original ResearchConceptsCatecholamine metabolitesMorphine withdrawal behaviorsBeta-receptor bindingWithdrawal behaviorDebrisoquin sulfateAcute treatmentMorphine withdrawalNorepinephrine metaboliteMorphine pelletsWithdrawal signsPlasma levelsBrain 3Noradrenergic hyperactivityReceptor bindingMHPGBrainMetabolitesNaloxoneHVARatsHyperactivity