1990
MPTP-induced parkinsonism: relative changes in dopamine concentration in subregions of substantia nigra, ventral tegmental area and retrorubral field of symptomatic and asymptomatic vervet monkeys
Elsworth J, Deutch A, Redmond D, Sladek J, Roth R. MPTP-induced parkinsonism: relative changes in dopamine concentration in subregions of substantia nigra, ventral tegmental area and retrorubral field of symptomatic and asymptomatic vervet monkeys. Brain Research 1990, 513: 320-324. PMID: 2350702, DOI: 10.1016/0006-8993(90)90474-p.Peer-Reviewed Original ResearchConceptsVentral tegmental areaSubstantia nigraTegmental areaRetrorubral fieldParkinson's diseasePostencephalitic Parkinson's diseaseHomovanillic acid concentrationsMesostriatal dopaminergic systemIdiopathic Parkinson's diseaseAsymptomatic monkeysSymptomatic monkeysDA neuronsHVA concentrationsMPTP toxicityTreatment regimensDopaminergic systemDopamine concentrationsDA regionsDiseaseNigraDopamineParkinsonismMonkeysVervet monkeysRegimens
1986
Preferential vulnerability of A8 dopamine neurons in the primate to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Deutch A, Elsworth J, Goldstein M, Fuxe K, Redmond D, Sladek J, Roth R. Preferential vulnerability of A8 dopamine neurons in the primate to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neuroscience Letters 1986, 68: 51-56. PMID: 3487756, DOI: 10.1016/0304-3940(86)90228-4.Peer-Reviewed Original ResearchConceptsA8 regionDA neuronsSubstantia nigraDopamine cell groupsDopaminergic neuronsDopamine neuronsImmunohistochemical examinationPreferential vulnerabilityHomovanillic acidBiochemical assessmentCell groupsMarked depletionNeuronsSame animalsSignificant decreaseMarked lossMPTPStriatumNigraVervet monkeysMidbrainTetrahydropyridine