1991
Anxiogenic β-carboline FG 7142 produces activation of noradrenergic neurons in specific brain regions of rats
Ida Y, Elsworth J, Roth R. Anxiogenic β-carboline FG 7142 produces activation of noradrenergic neurons in specific brain regions of rats. Pharmacology Biochemistry And Behavior 1991, 39: 791-793. PMID: 1784607, DOI: 10.1016/0091-3057(91)90166-y.Peer-Reviewed Original ResearchConceptsBrain noradrenergic activityFG 7142Specific brain regionsCerebral cortexNoradrenergic activityΒ-carboline FG 7142Brain regionsBeta-carboline FG 7142Rat brain noradrenalineBrain noradrenergic systemAntagonist Ro 15Brain noradrenalineAgonist clonidineNoradrenergic neuronsBZD receptorsMHPG levelsRo 15Sixty minNoradrenergic systemSame doseBenzodiazepine receptorsInverse agonistDihydroxyphenylglycolMajor metaboliteMetabolite levels
1988
Clonidine infusions into the locus coeruleus attenuate behavioral and neurochemical changes associated with naloxone-precipitated withdrawal
Taylor J, Elsworth J, Garcia E, Grant S, Roth R, Redmond D. Clonidine infusions into the locus coeruleus attenuate behavioral and neurochemical changes associated with naloxone-precipitated withdrawal. Psychopharmacology 1988, 96: 121-134. PMID: 3147472, DOI: 10.1007/bf02431544.Peer-Reviewed Original ResearchConceptsNaloxone-precipitated withdrawalDorsal parabrachial nucleusAlpha-2 adrenergic receptorsWet dog shakesLocus coeruleusClonidine infusionMHPG concentrationsOpiate withdrawalAlpha-2 adrenergic agonistsAnti-withdrawal actionWithdrawal-induced increasesBlood-brain barrierInfusion of clonidineNucleus locus coeruleusOccurrence of diarrheaClonidine's abilityLC infusionBrain concentrationsNoradrenergic neuronsST-91MHPG levelsPeripheral injectionWithdrawal signsNeurochemical changesParabrachial nucleus
1983
Panic-induced elevation of plasma MHPG levels in phobic-anxious patients. Effects of clonidine and imipramine
Ko G, Elsworth J, Roth R, Rifkin B, Leigh H, Redmond E. Panic-induced elevation of plasma MHPG levels in phobic-anxious patients. Effects of clonidine and imipramine. Journal Of Clinical Psychopharmacology 1983, 3: 328. DOI: 10.1097/00004714-198310000-00029.Peer-Reviewed Original ResearchPanic-Induced Elevation of Plasma MHPG Levels in Phobic-Anxious Patients: Effects of Clonidine and Imipramine
Ko G, Elsworth J, Roth R, Rifkin B, Leigh H, Redmond D. Panic-Induced Elevation of Plasma MHPG Levels in Phobic-Anxious Patients: Effects of Clonidine and Imipramine. JAMA Psychiatry 1983, 40: 425-430. PMID: 6838322, DOI: 10.1001/archpsyc.1983.01790040079011.Peer-Reviewed Original ResearchConceptsPlasma MHPG levelsMHPG levelsEffects of clonidineSignificant symptom reductionPlasma MHPG concentrationSelf-rated anxietyPlacebo treatmentCrossover trialMHPG concentrationsPlasma levelsNoradrenergic activityDrug treatmentDrug trialsSymptom reductionDiminished suppressionPanic attacksPanic symptomsImipramine hydrochlorideClonidinePatientsPhobic stimuliImipramineTrialsAnxietyTreatment