2001
Nicotine Receptor Inactivation Decreases Sensitivity to Cocaine
Zachariou V, Caldarone B, Weathers-Lowin A, George T, Elsworth J, Roth R, Changeux J, Picciotto M. Nicotine Receptor Inactivation Decreases Sensitivity to Cocaine. Neuropsychopharmacology 2001, 24: 576-589. PMID: 11282258, DOI: 10.1016/s0893-133x(00)00224-4.Peer-Reviewed Original ResearchConceptsPlace preferenceDA turnoverLow doseHigh-affinity nicotinic acetylcholine receptorsMesolimbic DA systemHigh-affinity nAChRsNicotinic antagonist mecamylamineWild-type miceMesolimbic dopamine systemFos-related antigensProperties of nicotineCocaine place preferenceΒ2 subunitNicotinic acetylcholine receptorsAntagonist mecamylamineDA releaseMetabolite DOPACNeurochemical changesSubthreshold doseType miceDopamine systemPsychomotor stimulantsAcetylcholine receptorsHigh dosesBrain regions
1990
Mesocortical dopamine neurons: High basal firing frequency predicts tyrosine dependence of dopamine synthesis
Tam S, Elsworth J, Bradberry C, Roth R. Mesocortical dopamine neurons: High basal firing frequency predicts tyrosine dependence of dopamine synthesis. Journal Of Neural Transmission 1990, 81: 97-110. PMID: 2363911, DOI: 10.1007/bf01245830.Peer-Reviewed Original ResearchConceptsMesoprefrontal DA neuronsDA neuronsTyrosine administrationDA levelsCingulate cortexPrefrontal cortexTyrosine hydroxylationAnxiogenic β-carbolineDA metabolite levelsDA terminal fieldsEndogenous DA levelsMesocortical DA neuronsMesocortical dopamine neuronsVivo tyrosine hydroxylationMidbrain DA neuronsTyrosine hydroxylase activityTransmitter outflowDA metabolitesDA synthesisDopamine neuronsFG 7142Dopamine synthesisTerminal fieldsTyrosine availabilityHigh doses