1988
Biochemical analysis of caudate nucleus biopsy samples from parkinsonian patients
Goldstein M, Lieberman A, Helmer E, Koslow M, Ransohoff J, Elsworth J, Roth R, Deutch A. Biochemical analysis of caudate nucleus biopsy samples from parkinsonian patients. Annals Of Neurology 1988, 24: 685-688. PMID: 2904793, DOI: 10.1002/ana.410240517.Peer-Reviewed Original ResearchConceptsBiopsy samplesAdrenal transplantationDopamine functionAutologous adrenal transplantationMetabolite homovanillic acidEnzyme tyrosine hydroxylaseConcentration of dopamineParkinsonian patientsTherapeutic responseHomovanillic acidParkinson's diseaseTyrosine hydroxylasePostmortem valuesBiochemical analysisBiochemical parametersPatientsTransplantationPostmortem changesDisease
1987
Homovanillic acid concentrations in brain, CSF and plasma as indicators of central dopamine function in primates
Elsworth J, Leahy D, Roth R, Redmond D. Homovanillic acid concentrations in brain, CSF and plasma as indicators of central dopamine function in primates. Journal Of Neural Transmission 1987, 68: 51-62. PMID: 3806086, DOI: 10.1007/bf01244639.Peer-Reviewed Original ResearchConceptsHomovanillic acid concentrationsDorsal frontal cortexFrontal cortexHVA concentrationsCentral dopamine functionCSF HVA concentrationsCentral dopamine metabolismBasal ganglia areaOrbital frontal cortexSignificant correlationPossible treatment effectsPlasma HVAGanglia areaDopamine metabolismCaudate nucleusCortical areasDopamine functionBrain areasCisternal CSFBrain regionsHVA measurementsCortex contributesCSFCortexOnly significant relationship