2001
Glial Cell Line-Derived Neurotrophic Factor (GDNF) Gene Delivery Protects Dopaminergic Terminals from Degeneration
Connor B, Kozlowski D, Unnerstall J, Elsworth J, Tillerson J, Schallert T, Bohn M. Glial Cell Line-Derived Neurotrophic Factor (GDNF) Gene Delivery Protects Dopaminergic Terminals from Degeneration. Experimental Neurology 2001, 169: 83-95. PMID: 11312561, DOI: 10.1006/exnr.2001.7638.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAutoradiographyCarrier ProteinsCocaineCorpus StriatumDisease Models, AnimalDopamineDopamine Plasma Membrane Transport ProteinsGenetic TherapyGenetic VectorsGlial Cell Line-Derived Neurotrophic FactorMaleMembrane GlycoproteinsMembrane Transport ProteinsMicroinjectionsMotor ActivityNerve Growth FactorsNerve Tissue ProteinsNeuronsNeurotransmitter AgentsOxidopamineParkinson Disease, SecondaryPresynaptic TerminalsRatsRats, Inbred F344RNA, MessengerSubstantia NigraTyrosine 3-MonooxygenaseConceptsGlial cell line-derived neurotrophic factorGDNF gene deliverySubstantia nigraDA terminalsDA neuronsNeuronal sproutingGlial cell line-derived neurotrophic factor (GDNF) gene deliveryAmphetamine-induced rotational asymmetryLine-derived neurotrophic factorUnilateral intrastriatal injectionAged rat brainDopaminergic neuronal functionTyrosine hydroxylase mRNADA transporter ligandsNigrostriatal functionStriatal injectionAxonal sproutingDopaminergic terminalsIntrastriatal injectionStriatal denervationDenervated striatumWeeks postlesionNeurotrophic factorNigrostriatal axonsPartial lesions
1998
Pattern of synaptophysin immunoreactivity within mesencephalic grafts following transplantation in a parkinsonian primate model
Sortwell C, Blanchard B, Collier T, Elsworth J, Taylor J, Roth R, Redmond D, Sladek J. Pattern of synaptophysin immunoreactivity within mesencephalic grafts following transplantation in a parkinsonian primate model. Brain Research 1998, 791: 117-124. PMID: 9593853, DOI: 10.1016/s0006-8993(98)00086-9.Peer-Reviewed Original ResearchConceptsGraft-host interactionsMesencephalic graftsFunctional synapsesTyrosine hydroxylaseCerebellar tissuePericellular arraysEmbryonic cerebellar tissueEmbryonic ventral mesencephalonGrafted dopamine neuronsNerve terminal differentiationTH-positive neuronsStriatum of MPTPEnzyme tyrosine hydroxylaseSynthetic enzyme tyrosine hydroxylaseAfrican green monkeysNeurochemical subtypesStriatal portionDA neuronsSynaptophysin immunoreactivityVentral mesencephalonGraft typeDopamine neuronsPrimate modelStriatal targetsSynaptic remodeling
1997
Metabolic energy capacity of dopaminergic grafts and the implanted striatum in parkinsonian nonhuman primates as visualized with cytochrome oxidase histochemistry
Collier T, Redmond D, Roth R, Elsworth J, Taylor J, Sladek J. Metabolic energy capacity of dopaminergic grafts and the implanted striatum in parkinsonian nonhuman primates as visualized with cytochrome oxidase histochemistry. Cell Transplantation 1997, 6: 135-140. DOI: 10.1016/s0963-6897(97)00003-1.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsBrain Tissue TransplantationChlorocebus aethiopsCorpus StriatumDopamineElectron Transport Complex IVEnergy MetabolismFetal Tissue TransplantationGestational AgeImmunohistochemistryMesencephalonNeuronsParkinson Disease, SecondaryTyrosine 3-MonooxygenaseConceptsDA neuronsEmbryonic ventral mesencephalic tissueParkinsonian nonhuman primatesStriatum of DATyrosine hydroxylase immunocytochemistryVentral mesencephalic tissueVentral mesencephalic graftsCytochrome oxidase histochemistryCytochrome oxidase stainingMitochondrial enzyme cytochrome oxidaseLocal energy metabolismActive innervationBilateral graftsNeuron contentDopaminergic graftsMesencephalic graftsMesencephalic tissueHost brainBrain metabolismEnzyme cytochrome oxidaseCO stainingTissue transplantsGraftMetabolic activityNonhuman primatesMetabolic Energy Capacity of Dopaminergic Grafts and the Implanted Striatum in Parkinsonian Nonhuman Primates as Visualized with Cytochrome Oxidase Histochemistry
Collier T, Redmond D, Roth R, Elsworth J, Taylor J, Sladek J. Metabolic Energy Capacity of Dopaminergic Grafts and the Implanted Striatum in Parkinsonian Nonhuman Primates as Visualized with Cytochrome Oxidase Histochemistry. Cell Transplantation 1997, 6: 135-140. PMID: 9142445, DOI: 10.1177/096368979700600207.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsBrain Tissue TransplantationChlorocebus aethiopsCorpus StriatumDopamineElectron Transport Complex IVEnergy MetabolismFetal Tissue TransplantationGestational AgeImmunohistochemistryMesencephalonNeuronsParkinson Disease, SecondaryTyrosine 3-MonooxygenaseConceptsDA neuronsEmbryonic ventral mesencephalic tissueParkinsonian nonhuman primatesStriatum of DATyrosine hydroxylase immunocytochemistryVentral mesencephalic tissueVentral mesencephalic graftsBrain energy metabolismCytochrome oxidase histochemistryCytochrome oxidase stainingMitochondrial enzyme cytochrome oxidaseLocal energy metabolismEnergy metabolismActive innervationBilateral graftsNeuron contentDopaminergic graftsMesencephalic graftsMesencephalic tissueHost brainEnzyme cytochrome oxidaseCO stainingTissue transplantsGraftMetabolic activity
1990
Mesocortical dopamine neurons: High basal firing frequency predicts tyrosine dependence of dopamine synthesis
Tam S, Elsworth J, Bradberry C, Roth R. Mesocortical dopamine neurons: High basal firing frequency predicts tyrosine dependence of dopamine synthesis. Journal Of Neural Transmission 1990, 81: 97-110. PMID: 2363911, DOI: 10.1007/bf01245830.Peer-Reviewed Original ResearchConceptsMesoprefrontal DA neuronsDA neuronsTyrosine administrationDA levelsCingulate cortexPrefrontal cortexTyrosine hydroxylationAnxiogenic β-carbolineDA metabolite levelsDA terminal fieldsEndogenous DA levelsMesocortical DA neuronsMesocortical dopamine neuronsVivo tyrosine hydroxylationMidbrain DA neuronsTyrosine hydroxylase activityTransmitter outflowDA metabolitesDA synthesisDopamine neuronsFG 7142Dopamine synthesisTerminal fieldsTyrosine availabilityHigh dosesMPTP-induced parkinsonism: relative changes in dopamine concentration in subregions of substantia nigra, ventral tegmental area and retrorubral field of symptomatic and asymptomatic vervet monkeys
Elsworth J, Deutch A, Redmond D, Sladek J, Roth R. MPTP-induced parkinsonism: relative changes in dopamine concentration in subregions of substantia nigra, ventral tegmental area and retrorubral field of symptomatic and asymptomatic vervet monkeys. Brain Research 1990, 513: 320-324. PMID: 2350702, DOI: 10.1016/0006-8993(90)90474-p.Peer-Reviewed Original ResearchConceptsVentral tegmental areaSubstantia nigraTegmental areaRetrorubral fieldParkinson's diseasePostencephalitic Parkinson's diseaseHomovanillic acid concentrationsMesostriatal dopaminergic systemIdiopathic Parkinson's diseaseAsymptomatic monkeysSymptomatic monkeysDA neuronsHVA concentrationsMPTP toxicityTreatment regimensDopaminergic systemDopamine concentrationsDA regionsDiseaseNigraDopamineParkinsonismMonkeysVervet monkeysRegimens
1987
Differential responsiveness to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in sub-regions of the primate substantia nigra and striatum
Elsworth J, Deutch A, Redmond D, Sladek J, Roth R. Differential responsiveness to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in sub-regions of the primate substantia nigra and striatum. Life Sciences 1987, 40: 193-202. PMID: 3491946, DOI: 10.1016/0024-3205(87)90359-6.Peer-Reviewed Original ResearchConceptsSubstantia nigraParkinsonian disabilityDA neuronsSymptomatic animalsMedial regionAsymptomatic animalsHVA/DA ratioLateral regionsDA concentrationPrimate substantia nigraDA histofluorescenceNigrostriatal pathwayTetrahydropyridine (MPTP) toxicityDopaminergic neuronsContralateral halfDA ratioDopaminergic cellsLipofuscin fluorescenceCell bodiesStriatumIndividual neuronsNeuronsDifferential responsivenessMarked lossDopamine
1986
Preferential vulnerability of A8 dopamine neurons in the primate to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Deutch A, Elsworth J, Goldstein M, Fuxe K, Redmond D, Sladek J, Roth R. Preferential vulnerability of A8 dopamine neurons in the primate to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neuroscience Letters 1986, 68: 51-56. PMID: 3487756, DOI: 10.1016/0304-3940(86)90228-4.Peer-Reviewed Original ResearchConceptsA8 regionDA neuronsSubstantia nigraDopamine cell groupsDopaminergic neuronsDopamine neuronsImmunohistochemical examinationPreferential vulnerabilityHomovanillic acidBiochemical assessmentCell groupsMarked depletionNeuronsSame animalsSignificant decreaseMarked lossMPTPStriatumNigraVervet monkeysMidbrainTetrahydropyridine