1983
Panic-Induced Elevation of Plasma MHPG Levels in Phobic-Anxious Patients: Effects of Clonidine and Imipramine
Ko G, Elsworth J, Roth R, Rifkin B, Leigh H, Redmond D. Panic-Induced Elevation of Plasma MHPG Levels in Phobic-Anxious Patients: Effects of Clonidine and Imipramine. JAMA Psychiatry 1983, 40: 425-430. PMID: 6838322, DOI: 10.1001/archpsyc.1983.01790040079011.Peer-Reviewed Original ResearchConceptsPlasma MHPG levelsMHPG levelsEffects of clonidineSignificant symptom reductionPlasma MHPG concentrationSelf-rated anxietyPlacebo treatmentCrossover trialMHPG concentrationsPlasma levelsNoradrenergic activityDrug treatmentDrug trialsSymptom reductionDiminished suppressionPanic attacksPanic symptomsImipramine hydrochlorideClonidinePatientsPhobic stimuliImipramineTrialsAnxietyTreatment
1977
DEPRENYL IN PARKINSON'S DISEASE
Lees A, Kohout L, Shaw K, Stern G, Elsworth J, Sandler M, Youdim M. DEPRENYL IN PARKINSON'S DISEASE. The Lancet 1977, 310: 791-795. PMID: 71602, DOI: 10.1016/s0140-6736(77)90725-5.Peer-Reviewed Original ResearchConceptsParkinson's diseaseDouble-blind crossover trialDoses of levodopaEarly morning akinesiaPeripheral decarboxylase inhibitorLevodopa-induced dyskinesiaTotal daily dosesMajority of patientsIdiopathic Parkinson's diseaseDose akinesiaUntreated patientsCrossover trialDosage reductionDaily dosesDecarboxylase inhibitorTherapeutic effectCheese effectLarge dosesPatientsLevodopaAlternate daysAkinesiaDeprenylDiseaseB inhibitor