1991
Anxiogenic β-carboline FG 7142 produces activation of noradrenergic neurons in specific brain regions of rats
Ida Y, Elsworth J, Roth R. Anxiogenic β-carboline FG 7142 produces activation of noradrenergic neurons in specific brain regions of rats. Pharmacology Biochemistry And Behavior 1991, 39: 791-793. PMID: 1784607, DOI: 10.1016/0091-3057(91)90166-y.Peer-Reviewed Original ResearchConceptsBrain noradrenergic activityFG 7142Specific brain regionsCerebral cortexNoradrenergic activityΒ-carboline FG 7142Brain regionsBeta-carboline FG 7142Rat brain noradrenalineBrain noradrenergic systemAntagonist Ro 15Brain noradrenalineAgonist clonidineNoradrenergic neuronsBZD receptorsMHPG levelsRo 15Sixty minNoradrenergic systemSame doseBenzodiazepine receptorsInverse agonistDihydroxyphenylglycolMajor metaboliteMetabolite levels
1990
Regionally specific alterations in the low-affinity GABAA receptor following perinatal exposure to diazepam
Gruen R, Elsworth J, Roth R. Regionally specific alterations in the low-affinity GABAA receptor following perinatal exposure to diazepam. Brain Research 1990, 514: 151-154. PMID: 2162709, DOI: 10.1016/0006-8993(90)90449-l.Peer-Reviewed Original ResearchConceptsLow-affinity GABAA receptorsPerinatal exposureGABAA receptorsAbility of GABAPerinatal periodAdult ratsBenzodiazepine receptorsCingulate cortexLow affinity formDiazepamSpecific alterationsSignificant decreaseReceptorsSignificant reductionExposureAffinity formAlterationsHypothalamusGABARatsCortex
1985
Tribulin: an endogenous monoamine oxidase inhibitor/benzodiazepine receptor ligand.
Sandler M, Glover V, Clow A, Elsworth J. Tribulin: an endogenous monoamine oxidase inhibitor/benzodiazepine receptor ligand. Progress In Clinical And Biological Research 1985, 192: 359-62. PMID: 3001762.Peer-Reviewed Original ResearchConceptsLactate-induced panic attacksBenzodiazepine receptor bindingBenzodiazepine receptor ligandsBenzodiazepine withdrawalBenzodiazepine receptorsLow molecular weight inhibitorsPanic attacksTribulin outputAnxiety disordersReceptor bindingMonoamine oxidaseReceptor ligandsAnimal brainsWeight inhibitorsHuman plasmaInhibitorsHuman urineTribulinMonoaminesBrainReceptorsUrine