2024
Exitron splicing of odor receptor genes in Drosophila
Shang X, Talross G, Carlson J. Exitron splicing of odor receptor genes in Drosophila. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2320277121. PMID: 38507450, PMCID: PMC10990081, DOI: 10.1073/pnas.2320277121.Peer-Reviewed Original ResearchConceptsExitron splicingOdorant receptor genesCases of alternative splicingCanonical open reading framesExpression of odorant receptor genesFunction of olfactory systemReceptor geneProtein-coding exonsOpen reading frameAlternative splicing eventsOlfactory receptor neuronsAlternative polyadenylationReading frameExon-intronEncode proteinsSplicing eventsAlternative splicingNon-coding RNAsStable proteinsPheromone receptorsReceptor neuronsOptogenetic activationPheromone stimulationSplicingNeuronal activity
2022
Sugar sensation and mechanosensation in the egg-laying preference shift of Drosophila suzukii
Wang W, Dweck H, Talross G, Zaidi A, Gendron J, Carlson J. Sugar sensation and mechanosensation in the egg-laying preference shift of Drosophila suzukii. ELife 2022, 11: e81703. PMID: 36398882, PMCID: PMC9674340, DOI: 10.7554/elife.81703.Peer-Reviewed Original ResearchConceptsEgg-laying preferenceTaste organsAgricultural pestsDrosophila suzukiiChannel genesStiff substratesDrosophilaTaste sensillaReceptor geneMechanosensory cuesFruit sugarsGenesMechanosensationTaste sensationBitter taste sensationSpeciesEggsSweet taste sensationMajor subsetSuzukiiPestsSugarsElectrophysiological responsesWeak preferenceVariety of changes
2014
The Drosophila IR20a Clade of Ionotropic Receptors Are Candidate Taste and Pheromone Receptors
Koh TW, He Z, Gorur-Shandilya S, Menuz K, Larter NK, Stewart S, Carlson JR. The Drosophila IR20a Clade of Ionotropic Receptors Are Candidate Taste and Pheromone Receptors. Neuron 2014, 83: 850-865. PMID: 25123314, PMCID: PMC4141888, DOI: 10.1016/j.neuron.2014.07.012.Peer-Reviewed Original ResearchConceptsPheromone receptorsIonotropic receptorsGustatory receptor genesMale mating behaviorAdaptive evolutionTaste neuronsMale forelegsDimorphic expressionConspecific femalesCladeMating behaviorReceptor geneGenesTaste organsFliesNeural circuitsTaste receptorsNeuronsReceptorsSexual behaviorExpressionDrosophilaInsectsComprehensive analysisCourtship
2008
A Regulatory Code for Neuron-Specific Odor Receptor Expression
Ray A, van Naters W, Carlson JR. A Regulatory Code for Neuron-Specific Odor Receptor Expression. PLOS Biology 2008, 6: e125. PMID: 18846726, PMCID: PMC2430909, DOI: 10.1371/journal.pbio.0060125.Peer-Reviewed Original ResearchConceptsOlfactory receptor neuronsORN classesAxon guidance genesOdor receptorsAmino acid sequenceMost olfactory receptor neuronsReceptor gene regulationDrosophila speciesPhylogenetic approachGene regulationGenome sequenceTranscription factorsIndividual olfactory receptor neuronsRegulatory elementsAcid sequenceChemosensory organsRegulatory codeGenetic analysisMaxillary palpsGenesLarge repertoireReceptor neuronsReceptor geneExpressionNeuron map
2007
Two Gr Genes Underlie Sugar Reception in Drosophila
Dahanukar A, Lei YT, Kwon JY, Carlson JR. Two Gr Genes Underlie Sugar Reception in Drosophila. Neuron 2007, 56: 503-516. PMID: 17988633, PMCID: PMC2096712, DOI: 10.1016/j.neuron.2007.10.024.Peer-Reviewed Original ResearchConceptsSubset of sugarsReporter gene expressionSugar-sensing neuronsDouble mutantSugar receptionMolecular basisGenetic analysisGene expressionGr5aDrosophilaReceptor geneSitu hybridizationGenesNeuronsGr64aPrimary receptorTaste receptorsDistinct projectionsReceptorsTemporal dynamicsSugarsMutantsBehavioral responsesLabellumReporterMechanisms of Odor Receptor Gene Choice in Drosophila
Ray A, van Naters Wv, Shiraiwa T, Carlson JR. Mechanisms of Odor Receptor Gene Choice in Drosophila. Neuron 2007, 53: 353-369. PMID: 17270733, PMCID: PMC1986798, DOI: 10.1016/j.neuron.2006.12.010.Peer-Reviewed Original ResearchConceptsReceptor gene choiceOlfactory receptor neuronsGene choiceNegative regulatory elementAsymmetric segregationAlternative splicingNegative feedback regulationSingle geneTranscription factorsORN classesRegulatory elementsCombinatorial codeDicistronic mRNACommon progenitorMutational analysisDrosophilaRegulatory factorsOlfactory organFeedback regulationOdor receptorsReceptor neuronsReceptor geneGenesNeuron mapReceptor repertoire
2005
Coexpression of Two Functional Odor Receptors in One Neuron
Goldman AL, van Naters W, Lessing D, Warr CG, Carlson JR. Coexpression of Two Functional Odor Receptors in One Neuron. Neuron 2005, 45: 661-666. PMID: 15748842, DOI: 10.1016/j.neuron.2005.01.025.Peer-Reviewed Original Research
2003
Drosophila Gr5a encodes a taste receptor tuned to trehalose
Chyb S, Dahanukar A, Wickens A, Carlson JR. Drosophila Gr5a encodes a taste receptor tuned to trehalose. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 14526-14530. PMID: 14523229, PMCID: PMC304113, DOI: 10.1073/pnas.2135339100.Peer-Reviewed Original ResearchConceptsG protein-coupled receptor genesDrosophila S2 cell lineS2 cell lineFirst functional expressionTaste receptorsHeterologous expressionGenetic analysisFunctional expressionGr5aTaste sensillaReceptor geneCell linesGenesLabellar sensillaExpressionSensillaTaste neuronsReceptorsRecent studiesLabellumSensory responsesFliesNeuronsTrehaloseFamilyIntegrating the Molecular and Cellular Basis of Odor Coding in the Drosophila Antenna
Dobritsa AA, van Naters W, Warr CG, Steinbrecht RA, Carlson JR. Integrating the Molecular and Cellular Basis of Odor Coding in the Drosophila Antenna. Neuron 2003, 37: 827-841. PMID: 12628173, DOI: 10.1016/s0896-6273(03)00094-1.Peer-Reviewed Original ResearchConceptsAb3A neuronsEctopic expressionTransgenic rescue experimentsWild-type cellsDrosophila olfactory systemOdor ligandsDeletion mutantsDrosophila antennaCells identifiesGene expressionRescue experimentsCellular mapsSexual dimorphismReceptor gene expressionCellular basisOr22aOdor receptorsReceptor geneSingle cellsGenesOlfactory systemExpressionOdor codingDendritic membraneCells
2001
A Gr receptor is required for response to the sugar trehalose in taste neurons of Drosophila
Dahanukar A, Foster K, van der Goes van Naters W, Carlson J. A Gr receptor is required for response to the sugar trehalose in taste neurons of Drosophila. Nature Neuroscience 2001, 4: 1182-1186. PMID: 11704765, DOI: 10.1038/nn765.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAnimals, Genetically ModifiedBase SequenceBehavior, AnimalCodonDose-Response Relationship, DrugDrosophilaFood, FormulatedGene DeletionGene Expression RegulationGenetic LinkageGTP-Binding ProteinsMaleMutationNeurons, AfferentPhenotypeProtein BiosynthesisReceptors, Cell SurfaceSucroseTasteTrehaloseX ChromosomeConceptsGR geneG protein-coupled receptor genesSugar trehaloseG protein-mediated signalingDrosophila genome databaseTransgenic rescue experimentsProtein-mediated signalingSpecificity of expressionGenome databaseTaste receptorsDifferent mutantsRescue experimentsGenesLarge familyGr5aDrosophilaFunctional evidenceReceptor geneGR receptorsTaste ligandsGustatory neuronsTaste neuronsTrehaloseReceptorsFamily members
1999
The Odor Specificities of a Subset of Olfactory Receptor Neurons Are Governed by Acj6, a POU-Domain Transcription Factor
Clyne P, Certel S, de Bruyne M, Zaslavsky L, Johnson W, Carlson J. The Odor Specificities of a Subset of Olfactory Receptor Neurons Are Governed by Acj6, a POU-Domain Transcription Factor. Neuron 1999, 22: 339-347. PMID: 10069339, DOI: 10.1016/s0896-6273(00)81094-6.Peer-Reviewed Original ResearchConceptsPOU domain transcription factorOlfactory neuronsTranscription factorsIndividual olfactory neuronsOdorant response profilesSubset of neuronsOlfactory receptor neuronsOdor specificityPhysiological analysisAcj6Neuronal identityOlfactory behaviorMolecular analysisReceptor neuronsNeuronsReceptor geneOlfactory codingGenesResponse profilesMutantsSpecificitySubset