2003
Molecular evolution of the insect chemoreceptor gene superfamily in Drosophila melanogaster
Robertson HM, Warr CG, Carlson JR. Molecular evolution of the insect chemoreceptor gene superfamily in Drosophila melanogaster. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 14537-14542. PMID: 14608037, PMCID: PMC304115, DOI: 10.1073/pnas.2335847100.Peer-Reviewed Original ResearchConceptsMolecular evolutionDrosophila melanogasterGustatory receptor proteinsAlternative splice formsN-terminal exonsGR geneChemoreceptor genesTandem clustersAncestral intronsAncient superfamilyDrosophila genomeIntron evolutionDivergent cladesAdditional intronPolymorphic pseudogenesInsect chemoreceptorCommon ancestorAlternative splicingPhylogenetic analysisGR familyOdorant receptorsSplice formsX chromosomeSugar trehaloseIntrons
2001
A Gr receptor is required for response to the sugar trehalose in taste neurons of Drosophila
Dahanukar A, Foster K, van der Goes van Naters W, Carlson J. A Gr receptor is required for response to the sugar trehalose in taste neurons of Drosophila. Nature Neuroscience 2001, 4: 1182-1186. PMID: 11704765, DOI: 10.1038/nn765.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAnimals, Genetically ModifiedBase SequenceBehavior, AnimalCodonDose-Response Relationship, DrugDrosophilaFood, FormulatedGene DeletionGene Expression RegulationGenetic LinkageGTP-Binding ProteinsMaleMutationNeurons, AfferentPhenotypeProtein BiosynthesisReceptors, Cell SurfaceSucroseTasteTrehaloseX ChromosomeConceptsGR geneG protein-coupled receptor genesSugar trehaloseG protein-mediated signalingDrosophila genome databaseTransgenic rescue experimentsProtein-mediated signalingSpecificity of expressionGenome databaseTaste receptorsDifferent mutantsRescue experimentsGenesLarge familyGr5aDrosophilaFunctional evidenceReceptor geneGR receptorsTaste ligandsGustatory neuronsTaste neuronsTrehaloseReceptorsFamily members