2024
Function and evolution of Ir52 receptors in mate detection in Drosophila
Luo Y, Talross G, Carlson J. Function and evolution of Ir52 receptors in mate detection in Drosophila. Current Biology 2024 PMID: 39471807, DOI: 10.1016/j.cub.2024.10.001.Peer-Reviewed Original ResearchMating partnersCluster of genesPotential mating partnersSexually dimorphic neuronsCourtship behaviorEvolutionary timeMate detectionExpression systemFly legFruit flyFly speciesSpeciesBiological problemsTaste neuronsMatingPheromone extractsFliesReceptorsDrosophilaCourtshipGenesNeuronsPheromoneCircuit mappingExpression
2022
Meeting a threat of the Anthropocene: Taste avoidance of metal ions by Drosophila
Xiao S, Baik LS, Shang X, Carlson JR. Meeting a threat of the Anthropocene: Taste avoidance of metal ions by Drosophila. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2204238119. PMID: 35700364, PMCID: PMC9231609, DOI: 10.1073/pnas.2204238119.Peer-Reviewed Original ResearchConceptsGenerations of exposureDipteran speciesAnthropogenic stressorsGR familyEnvironmental changesToxic chemical compoundsBitter-sensing neuronsTaste organsTaste receptorsAvoidance of feedingSugar-sensing neuronsElevated concentrationsZinc ionsDrosophilaChemical compoundsInsectsHuman activitiesBehavioral responsesReceptorsOrganismsFliesSpeciesNeuronsRapid rateDifferent subsets
2021
Sight of parasitoid wasps accelerates sexual behavior and upregulates a micropeptide gene in Drosophila
Ebrahim SAM, Talross GJS, Carlson JR. Sight of parasitoid wasps accelerates sexual behavior and upregulates a micropeptide gene in Drosophila. Nature Communications 2021, 12: 2453. PMID: 33907186, PMCID: PMC8079388, DOI: 10.1038/s41467-021-22712-0.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsAnimals, Genetically ModifiedBeta-Carotene 15,15'-MonooxygenaseCarnivoryDrosophilaDrosophila melanogasterDrosophila ProteinsDrosophila simulansFemaleFertilityGene Expression RegulationMaleNeuronsPattern Recognition, VisualReceptors, Ionotropic GlutamateReceptors, OdorantSexual Behavior, AnimalWaspsConceptsWasp speciesParasitoid waspsParasitoid wasp speciesInsect speciesAdult DrosophilaInsect worldMating behaviorMutational analysisGene expressionFemale fliesWaspsGenesDrosophilaSpeciesFliesDramatic upregulationDefensive responsesWidespread deathVisual circuitsInsectsMicropeptidesBehavioral responsesNervous systemHundreds of thousandsUnexpected responses
2019
Odor coding in the antenna of the tsetse fly Glossina morsitans
Soni N, Chahda JS, Carlson JR. Odor coding in the antenna of the tsetse fly Glossina morsitans. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 14300-14308. PMID: 31221757, PMCID: PMC6628836, DOI: 10.1073/pnas.1907075116.Peer-Reviewed Original ResearchConceptsTsetse fly Glossina morsitansClasses of sensillaFruit flyPhysiological analysisAlarm pheromoneDifferent response dynamicsOlfactory sensillaFly antennaOlfactory cuesCellular basisWide diversityTsetse fliesSensillaFliesDifferent functionsDifferent odor stimuliGlossina morsitansPheromoneTsetseFunctional organizationHostDrosophilaMorphological typesOdorantsStriking differenceChemosensory sensilla of the Drosophila wing express a candidate ionotropic pheromone receptor
He Z, Luo Y, Shang X, Sun JS, Carlson JR. Chemosensory sensilla of the Drosophila wing express a candidate ionotropic pheromone receptor. PLOS Biology 2019, 17: e2006619. PMID: 31112532, PMCID: PMC6528970, DOI: 10.1371/journal.pbio.2006619.Peer-Reviewed Original ResearchConceptsMale-female interactionsDrosophila wingSubesophageal zoneWing marginChemosensory sensillaRNA-seq analysisDifferential RNA-seq analysisAnterior wing marginMale-male interactionsPheromone receptorsTaste organsOptogenetic activationMolecular descriptionGenesIonotropic receptorsChemical perceptionSensillaSecond-order projectionsSexual behaviorFliesPheromoneMale sexual behaviorPheromonal inputHydrophobic moleculesActivationThe molecular and cellular basis of olfactory response to tsetse fly attractants
Chahda JS, Soni N, Sun JS, Ebrahim SAM, Weiss BL, Carlson JR. The molecular and cellular basis of olfactory response to tsetse fly attractants. PLOS Genetics 2019, 15: e1008005. PMID: 30875383, PMCID: PMC6420007, DOI: 10.1371/journal.pgen.1008005.Peer-Reviewed Original ResearchConceptsOlfactory receptor neuronsSensory pitsCellular basisHeterologous expression systemTsetse fly Glossina morsitansTerrestrial habitatsExpression systemGene expressionEmpty neuronAnimal matterOlfactory responsesSpecialized subtypesMajor vectorStrong attractantReceptor gene expressionG. fuscipesDrosophilaMalarial parasitesReceptor neuronsFliesAttractantsDevastating diseaseOlfactory systemBlood of humansGlossina morsitans
2014
The Drosophila IR20a Clade of Ionotropic Receptors Are Candidate Taste and Pheromone Receptors
Koh TW, He Z, Gorur-Shandilya S, Menuz K, Larter NK, Stewart S, Carlson JR. The Drosophila IR20a Clade of Ionotropic Receptors Are Candidate Taste and Pheromone Receptors. Neuron 2014, 83: 850-865. PMID: 25123314, PMCID: PMC4141888, DOI: 10.1016/j.neuron.2014.07.012.Peer-Reviewed Original ResearchConceptsPheromone receptorsIonotropic receptorsGustatory receptor genesMale mating behaviorAdaptive evolutionTaste neuronsMale forelegsDimorphic expressionConspecific femalesCladeMating behaviorReceptor geneGenesTaste organsFliesNeural circuitsTaste receptorsNeuronsReceptorsSexual behaviorExpressionDrosophilaInsectsComprehensive analysisCourtship
2003
Drosophila Gr5a encodes a taste receptor tuned to trehalose
Chyb S, Dahanukar A, Wickens A, Carlson JR. Drosophila Gr5a encodes a taste receptor tuned to trehalose. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 14526-14530. PMID: 14523229, PMCID: PMC304113, DOI: 10.1073/pnas.2135339100.Peer-Reviewed Original ResearchConceptsG protein-coupled receptor genesDrosophila S2 cell lineS2 cell lineFirst functional expressionTaste receptorsHeterologous expressionGenetic analysisFunctional expressionGr5aTaste sensillaReceptor geneCell linesGenesLabellar sensillaExpressionSensillaTaste neuronsReceptorsRecent studiesLabellumSensory responsesFliesNeuronsTrehaloseFamily