2024
Function and evolution of Ir52 receptors in mate detection in Drosophila
Luo Y, Talross G, Carlson J. Function and evolution of Ir52 receptors in mate detection in Drosophila. Current Biology 2024 PMID: 39471807, DOI: 10.1016/j.cub.2024.10.001.Peer-Reviewed Original ResearchMating partnersCluster of genesPotential mating partnersSexually dimorphic neuronsCourtship behaviorEvolutionary timeMate detectionExpression systemFly legFruit flyFly speciesSpeciesBiological problemsTaste neuronsMatingPheromone extractsFliesReceptorsDrosophilaCourtshipGenesNeuronsPheromoneCircuit mappingExpression
2022
Sugar sensation and mechanosensation in the egg-laying preference shift of Drosophila suzukii
Wang W, Dweck H, Talross G, Zaidi A, Gendron J, Carlson J. Sugar sensation and mechanosensation in the egg-laying preference shift of Drosophila suzukii. ELife 2022, 11: e81703. PMID: 36398882, PMCID: PMC9674340, DOI: 10.7554/elife.81703.Peer-Reviewed Original ResearchConceptsEgg-laying preferenceTaste organsAgricultural pestsDrosophila suzukiiChannel genesStiff substratesDrosophilaTaste sensillaReceptor geneMechanosensory cuesFruit sugarsGenesMechanosensationTaste sensationBitter taste sensationSpeciesEggsSweet taste sensationMajor subsetSuzukiiPestsSugarsElectrophysiological responsesWeak preferenceVariety of changesMeeting a threat of the Anthropocene: Taste avoidance of metal ions by Drosophila
Xiao S, Baik LS, Shang X, Carlson JR. Meeting a threat of the Anthropocene: Taste avoidance of metal ions by Drosophila. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2204238119. PMID: 35700364, PMCID: PMC9231609, DOI: 10.1073/pnas.2204238119.Peer-Reviewed Original ResearchConceptsGenerations of exposureDipteran speciesAnthropogenic stressorsGR familyEnvironmental changesToxic chemical compoundsBitter-sensing neuronsTaste organsTaste receptorsAvoidance of feedingSugar-sensing neuronsElevated concentrationsZinc ionsDrosophilaChemical compoundsInsectsHuman activitiesBehavioral responsesReceptorsOrganismsFliesSpeciesNeuronsRapid rateDifferent subsetsIr56b is an atypical ionotropic receptor that underlies appetitive salt response in Drosophila
Dweck HKM, Talross GJS, Luo Y, Ebrahim SAM, Carlson JR. Ir56b is an atypical ionotropic receptor that underlies appetitive salt response in Drosophila. Current Biology 2022, 32: 1776-1787.e4. PMID: 35294865, PMCID: PMC9050924, DOI: 10.1016/j.cub.2022.02.063.Peer-Reviewed Original ResearchConceptsSalt tasteBitter-sensing neuronsStop codonLoss of functionNumber of speciesIonotropic receptorsIonotropic receptor familyN-terminal regionReceptor familyNeuronsDrosophila speciesPremature stop codonTaste modalitiesAncient functionGR familySalt responseSense codonsMolecular basisAtypical memberSalt detectionModalitiesCodonSensory modalitiesDrosophilaBehavioral responses
2021
Sight of parasitoid wasps accelerates sexual behavior and upregulates a micropeptide gene in Drosophila
Ebrahim SAM, Talross GJS, Carlson JR. Sight of parasitoid wasps accelerates sexual behavior and upregulates a micropeptide gene in Drosophila. Nature Communications 2021, 12: 2453. PMID: 33907186, PMCID: PMC8079388, DOI: 10.1038/s41467-021-22712-0.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsAnimals, Genetically ModifiedBeta-Carotene 15,15'-MonooxygenaseCarnivoryDrosophilaDrosophila melanogasterDrosophila ProteinsDrosophila simulansFemaleFertilityGene Expression RegulationMaleNeuronsPattern Recognition, VisualReceptors, Ionotropic GlutamateReceptors, OdorantSexual Behavior, AnimalWaspsConceptsWasp speciesParasitoid waspsParasitoid wasp speciesInsect speciesAdult DrosophilaInsect worldMating behaviorMutational analysisGene expressionFemale fliesWaspsGenesDrosophilaSpeciesFliesDramatic upregulationDefensive responsesWidespread deathVisual circuitsInsectsMicropeptidesBehavioral responsesNervous systemHundreds of thousandsUnexpected responsesEvolutionary shifts in taste coding in the fruit pest Drosophila suzukii
Dweck HK, Talross GJ, Wang W, Carlson JR. Evolutionary shifts in taste coding in the fruit pest Drosophila suzukii. ELife 2021, 10: e64317. PMID: 33616529, PMCID: PMC7899650, DOI: 10.7554/elife.64317.Peer-Reviewed Original ResearchConceptsFruit pest Drosophila suzukiiRipe fruitPest Drosophila suzukiiEvolutionary shiftsBitter compoundsLays eggsAgricultural pestsDrosophila suzukiiBitter taste perceptionDrosophilaTaste sensillaSpeciesPhysiological responsesReduced expressionEggsTaste organsSensillaOverripe fruitsFruitTranscriptomeTaste codingSuzukiiMutantsLabellumPests
2019
Odor coding in the antenna of the tsetse fly Glossina morsitans
Soni N, Chahda JS, Carlson JR. Odor coding in the antenna of the tsetse fly Glossina morsitans. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 14300-14308. PMID: 31221757, PMCID: PMC6628836, DOI: 10.1073/pnas.1907075116.Peer-Reviewed Original ResearchConceptsTsetse fly Glossina morsitansClasses of sensillaFruit flyPhysiological analysisAlarm pheromoneDifferent response dynamicsOlfactory sensillaFly antennaOlfactory cuesCellular basisWide diversityTsetse fliesSensillaFliesDifferent functionsDifferent odor stimuliGlossina morsitansPheromoneTsetseFunctional organizationHostDrosophilaMorphological typesOdorantsStriking differenceThe molecular and cellular basis of olfactory response to tsetse fly attractants
Chahda JS, Soni N, Sun JS, Ebrahim SAM, Weiss BL, Carlson JR. The molecular and cellular basis of olfactory response to tsetse fly attractants. PLOS Genetics 2019, 15: e1008005. PMID: 30875383, PMCID: PMC6420007, DOI: 10.1371/journal.pgen.1008005.Peer-Reviewed Original ResearchConceptsOlfactory receptor neuronsSensory pitsCellular basisHeterologous expression systemTsetse fly Glossina morsitansTerrestrial habitatsExpression systemGene expressionEmpty neuronAnimal matterOlfactory responsesSpecialized subtypesMajor vectorStrong attractantReceptor gene expressionG. fuscipesDrosophilaMalarial parasitesReceptor neuronsFliesAttractantsDevastating diseaseOlfactory systemBlood of humansGlossina morsitans
2014
The Drosophila IR20a Clade of Ionotropic Receptors Are Candidate Taste and Pheromone Receptors
Koh TW, He Z, Gorur-Shandilya S, Menuz K, Larter NK, Stewart S, Carlson JR. The Drosophila IR20a Clade of Ionotropic Receptors Are Candidate Taste and Pheromone Receptors. Neuron 2014, 83: 850-865. PMID: 25123314, PMCID: PMC4141888, DOI: 10.1016/j.neuron.2014.07.012.Peer-Reviewed Original ResearchConceptsPheromone receptorsIonotropic receptorsGustatory receptor genesMale mating behaviorAdaptive evolutionTaste neuronsMale forelegsDimorphic expressionConspecific femalesCladeMating behaviorReceptor geneGenesTaste organsFliesNeural circuitsTaste receptorsNeuronsReceptorsSexual behaviorExpressionDrosophilaInsectsComprehensive analysisCourtship
2007
Two Gr Genes Underlie Sugar Reception in Drosophila
Dahanukar A, Lei YT, Kwon JY, Carlson JR. Two Gr Genes Underlie Sugar Reception in Drosophila. Neuron 2007, 56: 503-516. PMID: 17988633, PMCID: PMC2096712, DOI: 10.1016/j.neuron.2007.10.024.Peer-Reviewed Original ResearchConceptsSubset of sugarsReporter gene expressionSugar-sensing neuronsDouble mutantSugar receptionMolecular basisGenetic analysisGene expressionGr5aDrosophilaReceptor geneSitu hybridizationGenesNeuronsGr64aPrimary receptorTaste receptorsDistinct projectionsReceptorsTemporal dynamicsSugarsMutantsBehavioral responsesLabellumReporterReceptors and Neurons for Fly Odors in Drosophila
van Naters W, Carlson JR. Receptors and Neurons for Fly Odors in Drosophila. Current Biology 2007, 17: 606-612. PMID: 17363256, PMCID: PMC1876700, DOI: 10.1016/j.cub.2007.02.043.Peer-Reviewed Original ResearchConceptsCis-vaccenyl acetateOlfactory receptor neuronsTrichoid sensillaAnti-aphrodisiac pheromoneReceptor gene familyVirgin femalesVivo expression systemGene familyMate recognitionMating partnersDrosophila antennaExpression systemORN populationCellular basisReceptor neuronsYield responseSensillaMale extractsElectrophysiological analysisFood odorsReceptorsDrosophilaMajor typesPheromoneFemalesThe molecular basis of CO2 reception in Drosophila
Kwon JY, Dahanukar A, Weiss LA, Carlson JR. The molecular basis of CO2 reception in Drosophila. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 3574-3578. PMID: 17360684, PMCID: PMC1805529, DOI: 10.1073/pnas.0700079104.Peer-Reviewed Original ResearchConceptsMolecular basisVivo expression systemChemoreceptor genesHigher eukaryotesChemosensory receptorsInsect pestsChemosensory neuronsGene confersExpression systemLarge familyGr63aDrosophilaCO2 receptionGr21aInsectsMosquito vectorsIdentification of agentsEukaryotesPestsReceptorsGenesLarvaeIdentificationYellow feverConfersMechanisms of Odor Receptor Gene Choice in Drosophila
Ray A, van Naters Wv, Shiraiwa T, Carlson JR. Mechanisms of Odor Receptor Gene Choice in Drosophila. Neuron 2007, 53: 353-369. PMID: 17270733, PMCID: PMC1986798, DOI: 10.1016/j.neuron.2006.12.010.Peer-Reviewed Original ResearchConceptsReceptor gene choiceOlfactory receptor neuronsGene choiceNegative regulatory elementAsymmetric segregationAlternative splicingNegative feedback regulationSingle geneTranscription factorsORN classesRegulatory elementsCombinatorial codeDicistronic mRNACommon progenitorMutational analysisDrosophilaRegulatory factorsOlfactory organFeedback regulationOdor receptorsReceptor neuronsReceptor geneGenesNeuron mapReceptor repertoire
2001
A Gr receptor is required for response to the sugar trehalose in taste neurons of Drosophila
Dahanukar A, Foster K, van der Goes van Naters W, Carlson J. A Gr receptor is required for response to the sugar trehalose in taste neurons of Drosophila. Nature Neuroscience 2001, 4: 1182-1186. PMID: 11704765, DOI: 10.1038/nn765.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAnimals, Genetically ModifiedBase SequenceBehavior, AnimalCodonDose-Response Relationship, DrugDrosophilaFood, FormulatedGene DeletionGene Expression RegulationGenetic LinkageGTP-Binding ProteinsMaleMutationNeurons, AfferentPhenotypeProtein BiosynthesisReceptors, Cell SurfaceSucroseTasteTrehaloseX ChromosomeConceptsGR geneG protein-coupled receptor genesSugar trehaloseG protein-mediated signalingDrosophila genome databaseTransgenic rescue experimentsProtein-mediated signalingSpecificity of expressionGenome databaseTaste receptorsDifferent mutantsRescue experimentsGenesLarge familyGr5aDrosophilaFunctional evidenceReceptor geneGR receptorsTaste ligandsGustatory neuronsTaste neuronsTrehaloseReceptorsFamily members
2000
Candidate Taste Receptors in Drosophila
Clyne P, Warr C, Carlson J. Candidate Taste Receptors in Drosophila. Science 2000, 287: 1830-1834. PMID: 10710312, DOI: 10.1126/science.287.5459.1830.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAlternative SplicingAmino Acid SequenceAnimalsChemoreceptor CellsDrosophila melanogasterDrosophila ProteinsExonsGene ExpressionGenes, InsectIn Situ HybridizationInsect ProteinsMembrane ProteinsMolecular Sequence DataMultigene FamilyNeurons, AfferentOrgan SpecificityProtein Structure, TertiaryReceptors, Cell SurfaceReverse Transcriptase Polymerase Chain ReactionSense OrgansSequence AlignmentTasteConceptsDrosophila genome databaseTransmembrane domain proteinCandidate taste receptorsDomain proteinsDrosophila mutantsDivergent familiesGenome databaseTaste receptorsTissue specificityMolecular mechanismsDiverse familyGustatory organsGenesStructural similarityLabellumBasis of structureTaste signalingProteinTaste neuronsInitial eventFamilyExpressionDrosophilaMutantsReceptors