2024
Exitron splicing of odor receptor genes in Drosophila
Shang X, Talross G, Carlson J. Exitron splicing of odor receptor genes in Drosophila. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2320277121. PMID: 38507450, PMCID: PMC10990081, DOI: 10.1073/pnas.2320277121.Peer-Reviewed Original ResearchConceptsExitron splicingOdorant receptor genesCases of alternative splicingCanonical open reading framesExpression of odorant receptor genesFunction of olfactory systemReceptor geneProtein-coding exonsOpen reading frameAlternative splicing eventsOlfactory receptor neuronsAlternative polyadenylationReading frameExon-intronEncode proteinsSplicing eventsAlternative splicingNon-coding RNAsStable proteinsPheromone receptorsReceptor neuronsOptogenetic activationPheromone stimulationSplicingNeuronal activity
2007
Mechanisms of Odor Receptor Gene Choice in Drosophila
Ray A, van Naters Wv, Shiraiwa T, Carlson JR. Mechanisms of Odor Receptor Gene Choice in Drosophila. Neuron 2007, 53: 353-369. PMID: 17270733, PMCID: PMC1986798, DOI: 10.1016/j.neuron.2006.12.010.Peer-Reviewed Original ResearchConceptsReceptor gene choiceOlfactory receptor neuronsGene choiceNegative regulatory elementAsymmetric segregationAlternative splicingNegative feedback regulationSingle geneTranscription factorsORN classesRegulatory elementsCombinatorial codeDicistronic mRNACommon progenitorMutational analysisDrosophilaRegulatory factorsOlfactory organFeedback regulationOdor receptorsReceptor neuronsReceptor geneGenesNeuron mapReceptor repertoire
2003
Molecular evolution of the insect chemoreceptor gene superfamily in Drosophila melanogaster
Robertson HM, Warr CG, Carlson JR. Molecular evolution of the insect chemoreceptor gene superfamily in Drosophila melanogaster. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 14537-14542. PMID: 14608037, PMCID: PMC304115, DOI: 10.1073/pnas.2335847100.Peer-Reviewed Original ResearchConceptsMolecular evolutionDrosophila melanogasterGustatory receptor proteinsAlternative splice formsN-terminal exonsGR geneChemoreceptor genesTandem clustersAncestral intronsAncient superfamilyDrosophila genomeIntron evolutionDivergent cladesAdditional intronPolymorphic pseudogenesInsect chemoreceptorCommon ancestorAlternative splicingPhylogenetic analysisGR familyOdorant receptorsSplice formsX chromosomeSugar trehaloseIntrons