2024
Growth characteristics of HCT116 xenografts lacking asparagine synthetase vary according to sex
Aladelokun O, Lu L, Zheng J, Yan H, Jain A, Gibson J, Khan S, Johnson C. Growth characteristics of HCT116 xenografts lacking asparagine synthetase vary according to sex. Human Genomics 2024, 18: 67. PMID: 38886847, PMCID: PMC11184737, DOI: 10.1186/s40246-024-00635-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAspartate-Ammonia LigaseCarbon-Nitrogen Ligases with Glutamine as Amide-N-DonorCell ProliferationColorectal NeoplasmsFemaleGene Expression Regulation, NeoplasticHCT116 CellsHeterograftsHumansMaleMiceReceptors, EstrogenReceptors, G-Protein-CoupledSex FactorsXenograft Model Antitumor AssaysConceptsFemale tumor-bearing miceFemale CRC patientsTumor-bearing miceCRC patientsTumor growthInferior survivalAssociated with inferior survivalMetabolic reprogrammingG protein-coupled estrogen receptorTriggering metabolic reprogrammingSustained tumor growthSuppressed tumor growthExpression of asparagine synthetaseCancer cell linesBackgroundSex-related differencesSurvival improvementImpact of sexFemale miceEstrogen receptorCancer growthTranslational relevanceRewiring of metabolic pathwaysCancer burdenMetabolic pathwaysAsparagine synthetase
2022
Systems approach to enhance Lynch syndrome diagnosis through tumour testing
Singh V, Mezzacappa C, Gershkovich P, Di Giovanna J, Ganzak A, Gibson J, Sinard J, Xicola RM, Llor X. Systems approach to enhance Lynch syndrome diagnosis through tumour testing. Journal Of Medical Genetics 2022, 60: 533-539. PMID: 36115663, PMCID: PMC10020126, DOI: 10.1136/jmg-2022-108770.Peer-Reviewed Original ResearchConceptsOriginal cohortColorectal adenocarcinomaLynch syndromeTumor testingGenetic testingPercentage of patientsProportion of patientsLynch syndrome diagnosisCG evaluationCancer genetic testingRace/ethnicityCRC testingCohort studyMMR immunohistochemistryLS diagnosisNew diagnosisMMR lossAcademic centersPatientsSyndrome diagnosisCohortCase identificationMethylation testingReferral differencesReferral mechanisms
2021
Pathogenic BRCA2 germline variants in combined hepatocellular‐cholangiocarcinoma
Li H, Zhang X, Finberg KE, Walther Z, Jain D, Gibson J. Pathogenic BRCA2 germline variants in combined hepatocellular‐cholangiocarcinoma. Pathology International 2021, 72: 138-140. PMID: 34808016, DOI: 10.1111/pin.13188.Peer-Reviewed Case Reports and Technical NotesYale Cancer Center Precision Medicine Tumor Board: molecular findings alter a diagnosis and treatment plan
Gibson JA, Finberg KE, Nalbantoglu I, Cecchini M, Ganzak A, Walther Z, Sklar JL, Eder JP, Goldberg SB. Yale Cancer Center Precision Medicine Tumor Board: molecular findings alter a diagnosis and treatment plan. The Lancet Oncology 2021, 22: 306-307. PMID: 33662283, DOI: 10.1016/s1470-2045(20)30683-5.Peer-Reviewed Case Reports and Technical Notes
2011
Pathology of Diseases that Cause Upper Gastrointestinal Tract Bleeding
Gibson JA, Odze RD. Pathology of Diseases that Cause Upper Gastrointestinal Tract Bleeding. Gastrointestinal Endoscopy Clinics Of North America 2011, 21: 583-596. PMID: 21944412, DOI: 10.1016/j.giec.2011.07.006.Peer-Reviewed Original ResearchConceptsUpper gastrointestinal tractGastrointestinal tractUpper gastrointestinal tract bleedingGastrointestinal tract bleedingUpper gastrointestinal bleedingChronic bleedingTract bleedingGastrointestinal bleedingCommon indicationPathologic featuresSignificant morbidityChronic hemorrhagePathology of diseasesBleedingDiseaseTractHospitalizationMorbidityHemorrhageEndoscopyMortalityPathologyMUC Expression in Hyperplastic and Serrated Colonic Polyps
Gibson JA, Hahn HP, Shahsafaei A, Odze RD. MUC Expression in Hyperplastic and Serrated Colonic Polyps. The American Journal Of Surgical Pathology 2011, 35: 742-749. PMID: 21490447, DOI: 10.1097/pas.0b013e31821537a2.Peer-Reviewed Original ResearchConceptsSSA/PExpression of MUC6Hyperplastic polypsSerrated polypsSSA/PsPolyp groupRight colonMUC expressionColonic polypsSerrated colonic polypsSessile serrated adenomas/polypsSerrated adenomas/polypsTraditional serrated adenomasGoblet cell typeProgression of malignancyAdenomas/polypsIntensity of stainingDifferent anatomic locationsMicrovesicular typeSerrated carcinogenesisDifferential diagnosisMUC6 expressionAnatomic locationSerrated pathwaySerrated adenomas
2009
Mucosal Schwann Cell “Hamartoma”
Gibson JA, Hornick JL. Mucosal Schwann Cell “Hamartoma”. The American Journal Of Surgical Pathology 2009, 33: 781-787. PMID: 19065103, DOI: 10.1097/pas.0b013e31818dd6ca.Peer-Reviewed Original ResearchMeSH KeywordsActinsAgedAged, 80 and overAntigens, CD34Cell DifferentiationCell ProliferationClaudin-1Colonic PolypsColonoscopyColorectal NeoplasmsDiagnosis, DifferentialFemaleGlial Fibrillary Acidic ProteinHamartomaHumansImmunohistochemistryIncidental FindingsIntestinal MucosaMaleMembrane ProteinsMiddle AgedMucin-1Neurofibromatosis 1Neurofilament ProteinsNeuromaProto-Oncogene Proteins c-kitS100 ProteinsSchwann CellsConceptsLamina propriaHistologic featuresGanglion cellsSchwann cellsColorectal polypsNF1 patientsNeurofilament proteinDense eosinophilic cytoplasmGlial fibrillary acidic proteinSolitary colorectal polypsSimilar histologic featuresBland spindle cellsIndistinct cell bordersType 1 neurofibromatosisEpithelial membrane antigenFibrillary acidic proteinSchwann cell proliferationSmooth muscle actinUniform bland spindle cellsRare axonsMucosal biopsiesPositive axonsImmunohistochemical featuresNeural lesionsIntralesional heterogeneity
2007
Podoplanin (D2-40) Is a Novel Marker for Follicular Dendritic Cell Tumors
Yu H, Gibson JA, Pinkus GS, Hornick JL. Podoplanin (D2-40) Is a Novel Marker for Follicular Dendritic Cell Tumors. American Journal Of Clinical Pathology 2007, 128: 776-782. PMID: 17951199, DOI: 10.1309/7p8u659jbjcv6eeu.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntibodies, Monoclonal, Murine-DerivedBiomarkers, TumorCell MembraneDendritic Cell Sarcoma, FollicularDendritic Cells, FollicularDiagnosis, DifferentialFemaleHistiocytesHistiocytic SarcomaHumansImmunoenzyme TechniquesLymph NodesMembrane GlycoproteinsNeoplasm ProteinsSensitivity and SpecificitySoft Tissue NeoplasmsConceptsGastrointestinal stromal tumorsDendritic cell tumorInflammatory myofibroblastic tumorFollicular dendritic cell tumorFDC tumorSynovial sarcomaCell tumorsDendritic cellsKaposi's sarcomaMalignant peripheral nerve sheath tumorSpindle cell gastrointestinal stromal tumorPeripheral nerve sheath tumorsNodal Kaposi's sarcomaMonophasic synovial sarcomaNerve sheath tumorsLangerhans cell histiocytosisSolitary fibrous tumorSpindle cell lesionsMonoclonal antibody D2-40Antibody D2-40FDC markersInflammatory pseudotumorLymph nodesMassive lymphadenopathyMyofibroblastic tumor