Featured Publications
Social evolution of shared biofilm matrix components
Tai J, Mukherjee S, Nero T, Olson R, Tithof J, Nadell C, Yan J. Social evolution of shared biofilm matrix components. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2123469119. PMID: 35771939, PMCID: PMC9271185, DOI: 10.1073/pnas.2123469119.Peer-Reviewed Original ResearchMeSH KeywordsBacteriaExtracellular Polymeric Substance MatrixModels, BiologicalSocial EvolutionVibrio choleraeConceptsBiofilm matrix componentsCooperative public goodsMatrix componentsBiofilm formationBiofilm matrix proteinsMatrix productionSocial evolution theoryBiofilm spatial structureCell surface adhesionEvolutionary timescalesCell clustersRelatedness coefficientsBacterial communitiesBiofilm habitatAdhesion proteinsEvolutionary advantageEvolutionary stabilityMatrix proteinsAssociated analysis toolsDiffusible compoundsHost environmentSocial evolutionUbiquitous modeOutstanding questionsProteinMechanical forces drive a reorientation cascade leading to biofilm self-patterning
Nijjer J, Li C, Zhang Q, Lu H, Zhang S, Yan J. Mechanical forces drive a reorientation cascade leading to biofilm self-patterning. Nature Communications 2021, 12: 6632. PMID: 34789754, PMCID: PMC8599862, DOI: 10.1038/s41467-021-26869-6.Peer-Reviewed Original ResearchMeSH KeywordsBacterial AdhesionBiofilmsBiomechanical PhenomenaModels, BiologicalMutationVibrio choleraeConceptsVibrio cholerae biofilmsSurface-attached aggregatesBacterial communitiesCell-surface interactionsDevelopmental processesBiofilm developmentBacterial cellsCell reorientationExtracellular matrixNonadherent mutantsDifferential growthBacterial biofilmsMechanical forcesBiofilmsBacterial growthDifferential orderingCellsGrowthMutantsLarge collection
2024
Agent-based modeling of stress anisotropy driven nematic ordering in growing biofilms
Li C, Nijjer J, Feng L, Zhang Q, Yan J, Zhang S. Agent-based modeling of stress anisotropy driven nematic ordering in growing biofilms. Soft Matter 2024, 20: 3401-3410. PMID: 38563244, PMCID: PMC11041162, DOI: 10.1039/d3sm01535a.Peer-Reviewed Original ResearchConceptsStress anisotropyShear stressShear stress relaxationHigh shear stressLow shear stressHydrostatic stressStress relaxationBiomedical applicationsTime delayComplex multicellular patternsMicroscopy imagesSpatial organization of cellsThree-dimensionalCell orderingNematic orderOrganization of cellsMulticellular patternsSpatiotemporal correlationAgarose gelBacterial biofilmsStressBiofilmStress landscapeGrowth conditionsAnisotropy