Featured Publications
Social evolution of shared biofilm matrix components
Tai J, Mukherjee S, Nero T, Olson R, Tithof J, Nadell C, Yan J. Social evolution of shared biofilm matrix components. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2123469119. PMID: 35771939, PMCID: PMC9271185, DOI: 10.1073/pnas.2123469119.Peer-Reviewed Original ResearchConceptsBiofilm matrix componentsCooperative public goodsMatrix componentsBiofilm formationBiofilm matrix proteinsMatrix productionSocial evolution theoryBiofilm spatial structureCell surface adhesionEvolutionary timescalesCell clustersRelatedness coefficientsBacterial communitiesBiofilm habitatAdhesion proteinsEvolutionary advantageEvolutionary stabilityMatrix proteinsAssociated analysis toolsDiffusible compoundsHost environmentSocial evolutionUbiquitous modeOutstanding questionsProtein
2022
Bacterial Surface Detachment during Nebulization with Contaminated Reusable Home Nebulizers
Harris JC, Collins MS, Huang PH, Schramm CM, Nero T, Yan J, Murray TS. Bacterial Surface Detachment during Nebulization with Contaminated Reusable Home Nebulizers. Microbiology Spectrum 2022, 10: e02535-21. PMID: 35107362, PMCID: PMC8809330, DOI: 10.1128/spectrum.02535-21.Peer-Reviewed Original ResearchConceptsAlbuterol nebulizationNebulized therapyHome nebulizersCystic fibrosisChronic respiratory diseasesAerosolized medicationsLung infectionCF patientsRespiratory diseasePathogenic bacteriaPatientsNext Generation ImpactorClinical isolatesMedicationsLungPari LCTherapyAnonymous patientsClinical bacteriaNebulizationNebulizerAerosolizationPathogenic microbesDetachmentSubset of bacteria
2021
CO 2 -Driven diffusiophoresis for maintaining a bacteria-free surface
Shim S, Khodaparast S, Lai CY, Yan J, Ault JT, Rallabandi B, Shardt O, Stone HA. CO 2 -Driven diffusiophoresis for maintaining a bacteria-free surface. Soft Matter 2021, 17: 2568-2576. PMID: 33514979, DOI: 10.1039/d0sm02023k.Peer-Reviewed Original ResearchConceptsWild-type V. choleraeCell shapeBacterial cellsDirectional migrationV. choleraeCO2 gradientNonzero surface chargeP. aeruginosaCellsCO2 sourcesFlagellaCO2 concentration gradientBacteriaCholeraeDirectional responseBacteria-free surfaceGram stainMotilityAnti-biofouling surfacesConcentration gradientGradientAeruginosa
2019
Surviving as a Community: Antibiotic Tolerance and Persistence in Bacterial Biofilms
Yan J, Bassler B. Surviving as a Community: Antibiotic Tolerance and Persistence in Bacterial Biofilms. Cell Host & Microbe 2019, 26: 15-21. PMID: 31295420, PMCID: PMC6629468, DOI: 10.1016/j.chom.2019.06.002.Peer-Reviewed Original ResearchConceptsSurface-associated bacterial communitiesSingle-cell resolutionBiofilm formation processBiofilm resilienceBacterial communitiesPersister cellsAntibiotic toleranceBacterial toleranceBacterial biofilmsBiofilmsBacterial recurrenceToleranceAntibiotic resistanceRecent progressPersistencePhenotypeBiofilm eradicationNew strategyCommunityCellsHarmful role