Featured Publications
Morphogenesis and cell ordering in confined bacterial biofilms
Zhang Q, Li J, Nijjer J, Lu H, Kothari M, Alert R, Cohen T, Yan J. Morphogenesis and cell ordering in confined bacterial biofilms. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2107107118. PMID: 34330824, PMCID: PMC8346881, DOI: 10.1073/pnas.2107107118.Peer-Reviewed Original ResearchConceptsInherent developmental programsBiofilm-dwelling cellsBiofilm-forming speciesSingle-cell imagingDevelopmental programSpecific matrix componentsCell orderingBiofilm developmentSpherical biofilmsBacterial cellsCell communityExtracellular matrixBiofilm morphologyBacterial biofilmsBiophysical mechanismsMatrix componentsHost tissuesBiofilmsBiofilm growthStiff gelsCellsMorphogenesisMutagenesisSpeciesVibrio
2017
Extracellular-matrix-mediated osmotic pressure drives Vibrio cholerae biofilm expansion and cheater exclusion
Yan J, Nadell CD, Stone HA, Wingreen NS, Bassler BL. Extracellular-matrix-mediated osmotic pressure drives Vibrio cholerae biofilm expansion and cheater exclusion. Nature Communications 2017, 8: 327. PMID: 28835649, PMCID: PMC5569112, DOI: 10.1038/s41467-017-00401-1.Peer-Reviewed Original ResearchConceptsBiofilm-forming bacterial speciesSurface-attached communitiesVibrio choleraeActive cell growthModel organismsMatrix-producing cellsBacterial lifeNutrient uptakeEnvironmental perturbationsBacterial speciesBacterial cellsPlanktonic cellsSubmerged biofilmsExtracellular matrixCell growthMatrix productionOsmotic pressureBiofilm growthBiofilmsCholeraeCellsPhysical exclusionMatrix crosslinkingOsmotic swellingGrowth