Featured Publications
Social evolution of shared biofilm matrix components
Tai J, Mukherjee S, Nero T, Olson R, Tithof J, Nadell C, Yan J. Social evolution of shared biofilm matrix components. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2123469119. PMID: 35771939, PMCID: PMC9271185, DOI: 10.1073/pnas.2123469119.Peer-Reviewed Original ResearchConceptsBiofilm matrix componentsCooperative public goodsMatrix componentsBiofilm formationBiofilm matrix proteinsMatrix productionSocial evolution theoryBiofilm spatial structureCell surface adhesionEvolutionary timescalesCell clustersRelatedness coefficientsBacterial communitiesBiofilm habitatAdhesion proteinsEvolutionary advantageEvolutionary stabilityMatrix proteinsAssociated analysis toolsDiffusible compoundsHost environmentSocial evolutionUbiquitous modeOutstanding questionsProtein
2023
New Insights into Vibrio cholerae Biofilms from Molecular Biophysics to Microbial Ecology
Tai J, Ferrell M, Yan J, Waters C. New Insights into Vibrio cholerae Biofilms from Molecular Biophysics to Microbial Ecology. Advances In Experimental Medicine And Biology 2023, 1404: 17-39. PMID: 36792869, PMCID: PMC10726288, DOI: 10.1007/978-3-031-22997-8_2.Peer-Reviewed Original ResearchConceptsV. cholerae biofilmsBacterial signal transduction networkSignal transduction networksBiofilm formationVibrio cholerae biofilmsKey model systemV. choleraeEcological roleMicrobial ecologyTransduction networksBiofilm maturationEnvironmental survivalCholera pathogenesisMolecular biophysicsRegulatory systemVibrio choleraeEl Tor biotypeBacterial surface attachmentRecent insightsModel systemBiofilmsLife cycleSurface attachmentCholeraeCentral function
2019
Mechanical instability and interfacial energy drive biofilm morphogenesis
Yan J, Fei C, Mao S, Moreau A, Wingreen NS, Košmrlj A, Stone HA, Bassler BL. Mechanical instability and interfacial energy drive biofilm morphogenesis. ELife 2019, 8: e43920. PMID: 30848725, PMCID: PMC6453567, DOI: 10.7554/elife.43920.Peer-Reviewed Original ResearchConceptsSurface-attached bacterial communityBiofilm morphogenesisMorphogenesis programHigher organismsBiofilm expansionDiversity of morphologiesBacterial communitiesBiofilm surface morphologyRegulatory componentsBiofilm formationBacterial biofilmsModel systemEssential constituentBiofilmsMorphogenesisMutagenesisQuantitative image analysisOrganismsDiversityVibrio
2017
Environmental fluctuation governs selection for plasticity in biofilm production
Yan J, Nadell CD, Bassler BL. Environmental fluctuation governs selection for plasticity in biofilm production. The ISME Journal: Multidisciplinary Journal Of Microbial Ecology 2017, 11: 1569-1577. PMID: 28338673, PMCID: PMC5520152, DOI: 10.1038/ismej.2017.33.Peer-Reviewed Original ResearchConceptsHuman pathogen Vibrio choleraePlanktonic growthFree-swimming stateBiofilm formationPathogen Vibrio choleraeSurface-attached communitiesWild-type V. choleraeNon-producing mutantsBiofilm growth modeCell-cell interactionsSuch flexible strategiesBiofilm productionHabitat turnoverPhenotypic flexibilityCompetitive fitnessMolecular programsCompetitive abilityEnvironmental fluctuationsPlanktonic phaseWild typeBiofilm conditionsPlanktonic conditionsEcological conditionsNutrient accessBiofilm producers