2021
Mechanism of Inhibition of the Reproduction of SARS-CoV‑2 and Ebola Viruses by Remdesivir
Wang J, Reiss K, Shi Y, Lolis E, Lisi GP, Batista VS. Mechanism of Inhibition of the Reproduction of SARS-CoV‑2 and Ebola Viruses by Remdesivir. Biochemistry 2021, 60: 1869-1875. PMID: 34110129, PMCID: PMC8204756, DOI: 10.1021/acs.biochem.1c00292.Peer-Reviewed Original ResearchStructural analyses of an RNA stability element interacting with poly(A)
Torabi SF, Chen YL, Zhang K, Wang J, DeGregorio SJ, Vaidya AT, Su Z, Pabit SA, Chiu W, Pollack L, Steitz JA. Structural analyses of an RNA stability element interacting with poly(A). Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2026656118. PMID: 33785601, PMCID: PMC8040590, DOI: 10.1073/pnas.2026656118.Peer-Reviewed Original ResearchConceptsRNA stability elementCis-acting RNA elementsGlobal conformational changesRich internal loopCryo-electron microscopyRice transposable elementsDiverse genomesDouble-helical regionsSmall-angle X-ray scatteringEne motifTransposable elementsGlobal structural changesRNA interactionsRNA stabilityBioinformatics studiesRNA elementsStability elementShort helixConformational changesDecay pathwaysInternal loopBiochemical structureTriplex structureBindingMotif
2016
On the interpretation of electron microscopic maps of biological macromolecules
Wang J, Moore PB. On the interpretation of electron microscopic maps of biological macromolecules. Protein Science 2016, 26: 122-129. PMID: 27706888, PMCID: PMC5192980, DOI: 10.1002/pro.3060.Peer-Reviewed Original Research
2011
Structural Basis of Cooperative Ligand Binding by the Glycine Riboswitch
Butler EB, Xiong Y, Wang J, Strobel SA. Structural Basis of Cooperative Ligand Binding by the Glycine Riboswitch. Cell Chemical Biology 2011, 18: 293-298. PMID: 21439473, PMCID: PMC3076126, DOI: 10.1016/j.chembiol.2011.01.013.Peer-Reviewed Original ResearchConceptsGlycine riboswitchStructural basisGene expressionÅ crystal structureTandem riboswitchesCooperative ligand bindingRiboswitchLigand bindingTandem pairMinor contactsBinding sitesAmino acid ligandsCooperative recognitionExpressionExtensive networkOperonFusobacterium nucleatumAptamerCrystal structureGlycine binding siteBindingLigandsInteractionAcid ligands
2005
Hydrodynamic Characterization of the DEAD-box RNA Helicase DbpA
Talavera MA, Matthews EE, Eliason WK, Sagi I, Wang J, Henn A, De La Cruz EM. Hydrodynamic Characterization of the DEAD-box RNA Helicase DbpA. Journal Of Molecular Biology 2005, 355: 697-707. PMID: 16325852, DOI: 10.1016/j.jmb.2005.10.058.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid MotifsChromatography, GelComputersCross-Linking ReagentsDEAD-box RNA HelicasesElectrophoretic Mobility Shift AssayEscherichia coliEscherichia coli ProteinsModels, BiologicalModels, MolecularProtein Structure, TertiaryRNARNA HelicasesRNA-Binding ProteinsStructural Homology, ProteinConceptsHelicase core domainNucleic acid helicasesCarboxyl-terminal domainAb initio structure prediction methodNucleic acid unwindingHelicase activityRNA metabolismHydrodynamic bead modelingDistinct RNARNA substratesHairpin 92ATP hydrolysisStructural homologyStructure prediction methodsCore domainOligomeric formsAnalytical ultracentrifugationDbpAProtein AMulti-angle laserBead modelingRNASize exclusion chromatographyKey roleFunctional properties
2004
RNA kink turns to the left and to the right
Strobel SA, Adams PL, Stahley MR, Wang J. RNA kink turns to the left and to the right. RNA 2004, 10: 1852-1854. PMID: 15547133, PMCID: PMC1370673, DOI: 10.1261/rna.7141504.Peer-Reviewed Original Research