Analysis of PKR Structure by Small-Angle Scattering
VanOudenhove J, Anderson E, Krueger S, Cole J. Analysis of PKR Structure by Small-Angle Scattering. Journal Of Molecular Biology 2009, 387: 910-920. PMID: 19232355, PMCID: PMC2663012, DOI: 10.1016/j.jmb.2009.02.019.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid MotifsAmino Acid SequenceAnimalsBinding SitesDimerizationEIF-2 KinaseHumansImmunity, InnateModels, MolecularMolecular Sequence DataProtein ConformationProtein Structure, QuaternaryProtein Structure, TertiaryRNA, Double-StrandedScattering, Small AngleSequence Homology, Amino AcidX-Ray DiffractionConceptsProtein kinase RDouble-stranded RNATandem double-stranded RNAC-terminal kinase domainN-terminal double-stranded RNAFamily of proteinsInterdomain linker regionAntiviral defense pathwayDefense pathwaysAutophosphorylation reactionKinase domainRNA activatorUnstructured regionsLinker regionFlexible linkerRNAExtended conformationSmall-angle X-ray scatteringDiverse structuresGuinier analysisDistance distribution functionConformationKinaseKey componentX-ray scattering