PSA regulates androgen receptor expression in prostate cancer cells
Saxena P, Trerotola M, Wang T, Li J, Sayeed A, VanOudenhove J, Adams D, FitzGerald T, Altieri D, Languino L. PSA regulates androgen receptor expression in prostate cancer cells. The Prostate 2011, 72: 769-776. PMID: 21956655, PMCID: PMC3404455, DOI: 10.1002/pros.21482.Peer-Reviewed Original ResearchConceptsProstate-specific antigenAndrogen receptorC4-2B cellsShort hairpin RNAPrCa cellsAndrogen-independent cell linesAndrogen receptor expressionProtein levelsAR transcriptional activityAR protein levelsAR mRNA levelsProstate cancer progressionProstate cancer cellsTransient siRNA knockdownStable short hairpin RNAAR activatorsPSA levelsAR expressionEffect of downregulationPhosphorylation of SrcSerum biomarkersAR mRNAReceptor expressionAR levelsReal-time PCR