Using evolutionary genomics, transcriptomics, and systems biology to reveal gene networks underlying fungal development
Wang Z, Gudibanda A, Ugwuowo U, Trail F, Townsend J. Using evolutionary genomics, transcriptomics, and systems biology to reveal gene networks underlying fungal development. Fungal Biology Reviews 2018, 32: 249-264. DOI: 10.1016/j.fbr.2018.02.001.ChaptersModel speciesFungal developmentGenome-wide gene expression dataEvolutionary developmental biologyEvo-devo researchGenome-wide analysisSystems biology strategiesGene expression dataEvolutionary genomicsSpecies phylogenyGenetic screenDevelopmental biologyDevelopmental traitsGene networksRegulatory networksFungal modelCell biologyModern biologyFossil recordKnockout strategiesDevelopmental processesMultiple speciesSystems biologyMolecular geneticsExpression dataDevelopmental Dynamics of Long Noncoding RNA Expression during Sexual Fruiting Body Formation in Fusarium graminearum
Kim W, Miguel-Rojas C, Wang J, Townsend JP, Trail F. Developmental Dynamics of Long Noncoding RNA Expression during Sexual Fruiting Body Formation in Fusarium graminearum. MBio 2018, 9: 10.1128/mbio.01292-18. PMID: 30108170, PMCID: PMC6094484, DOI: 10.1128/mbio.01292-18.Peer-Reviewed Original ResearchConceptsSmall RNA clustersSubset of lncRNAsRole of lncRNAsBody formationRNA clustersAntisense lncRNAsSexual developmentDevelopmental stage-specific expression patternsStage-specific expression patternsVegetative growthNonsense-mediated decay pathwayFundamental genomic resourcesMeiotic stagesHundreds of lncRNAsSense-antisense pairsGenome-wide analysisRNA surveillance systemLong Noncoding RNA ExpressionPlant pathogenic fungiNoncoding RNA ExpressionKey regulatory componentOpposite DNA strandsFruiting-body formationMajor staple cropDevelopmental transcriptome