Plasma Levels of MicroRNA-155 Are Upregulated with Long-Term Left Ventricular Assist Device Support
Wang T, O’Brien E, Rogers JG, Jacoby DL, Chen ME, Testani JM, Bowles DE, Milano CA, Felker GM, Patel CB, Bonde PN, Ahmad T. Plasma Levels of MicroRNA-155 Are Upregulated with Long-Term Left Ventricular Assist Device Support. ASAIO Journal 2017, 63: 536-541. PMID: 28319523, PMCID: PMC5585122, DOI: 10.1097/mat.0000000000000564.Peer-Reviewed Original ResearchConceptsLVAD supportHeart failureMechanically Assisted Circulatory Support level 1Continuous-flow LVAD implantationLong-term LVAD supportMiR-155Ventricular assist device therapyMicroRNA-155Ventricular assist device supportPost-LVAD placementAdverse clinical outcomesAssist device supportPlasma expression levelsSupport level 1Real-time polymerase chain reactionQuantitative real-time polymerase chain reactionRelative quantification valuesContinuous blood flowWilcoxon signed-rank testMultiple biologic processesLVAD physiologyMeasurement of miRNAsInteragency RegistryLVAD implantationHF pathogenesis