2023
Baseline skin cytokine profiles determined by RNA in situ hybridization correlate with response to dupilumab in patients with eczematous dermatitis
Singh K, Valido K, Swallow M, Okifo K, Wang A, Cohen J, Damsky W. Baseline skin cytokine profiles determined by RNA in situ hybridization correlate with response to dupilumab in patients with eczematous dermatitis. Journal Of The American Academy Of Dermatology 2023, 88: 1094-1100. PMID: 36780951, DOI: 10.1016/j.jaad.2022.12.052.Peer-Reviewed Original ResearchConceptsEczematous dermatitisHistologic featuresTreatment selectionType 1Type 3 inflammationInflammatory skin diseaseCertain histologic featuresSitu hybridization correlatesClinical responseNonresponder groupCytokine profileCytokine stainingAtopic dermatitisCytokine RNAEczematous disordersSitu hybridizationDupilumabIL13 expressionSkin diseasesType 2PatientsDermatitisNonrespondersMolecular heterogeneityImproved response
2020
Paradoxical eruptions to targeted therapies in dermatology: A systematic review and analysis
Murphy MJ, Cohen JM, Vesely MD, Damsky W. Paradoxical eruptions to targeted therapies in dermatology: A systematic review and analysis. Journal Of The American Academy Of Dermatology 2020, 86: 1080-1091. PMID: 33307146, DOI: 10.1016/j.jaad.2020.12.010.Peer-Reviewed Original ResearchConceptsParadoxical reactionSystematic reviewNecrosis factor α inhibitorsTumor necrosis factor αSpectrum of manifestationsNecrosis factor αAntibody-based therapiesInterleukin-12/23IL-23IL-12/23Clinical featuresCutaneous reactionsEczematous eruptionInflammatory disordersProinflammatory cytokinesΑ inhibitorsRetrospective analysisIL-4RαFactor αPotential mechanismsDermatologyTherapyInhibitorsAntibodiesReaction patterns