High Single Doses of Radiation May Induce Elevated Levels of Hypoxia in Early-Stage Non-Small Cell Lung Cancer Tumors
Kelada OJ, Decker RH, Nath SK, Johung KL, Zheng MQ, Huang Y, Gallezot JD, Liu C, Carson RE, Oelfke U, Carlson DJ. High Single Doses of Radiation May Induce Elevated Levels of Hypoxia in Early-Stage Non-Small Cell Lung Cancer Tumors. International Journal Of Radiation Oncology • Biology • Physics 2018, 102: 174-183. PMID: 30102194, PMCID: PMC6092043, DOI: 10.1016/j.ijrobp.2018.05.032.Peer-Reviewed Original ResearchMeSH KeywordsAgedCarcinoma, Non-Small-Cell LungCohort StudiesDose-Response Relationship, RadiationFemaleHumansLung NeoplasmsMaleNeoplasm StagingPositron-Emission TomographyRadiosurgeryTumor HypoxiaConceptsStereotactic body radiation therapyTumor hypoxic volumeHigh single dosesNon-small cell lung cancer (NSCLC) tumorsCell lung cancer tumorsLung cancer tumorsSingle dosesTumor hypoxiaTreatment failureNSCLC tumorsBlood ratioHypoxic volumeRadiation therapyDay 2F-fluoromisonidazole (FMISO) positron emission tomographyCancer tumorsInstitutional review board-approved studyTumor vascular responseBody radiation therapyBoard-approved studyConventional radiation therapyPositron emission tomographyBaseline hypoxiaDetectable hypoxiaNSCLC patients