2018
High Single Doses of Radiation May Induce Elevated Levels of Hypoxia in Early-Stage Non-Small Cell Lung Cancer Tumors
Kelada OJ, Decker RH, Nath SK, Johung KL, Zheng MQ, Huang Y, Gallezot JD, Liu C, Carson RE, Oelfke U, Carlson DJ. High Single Doses of Radiation May Induce Elevated Levels of Hypoxia in Early-Stage Non-Small Cell Lung Cancer Tumors. International Journal Of Radiation Oncology • Biology • Physics 2018, 102: 174-183. PMID: 30102194, PMCID: PMC6092043, DOI: 10.1016/j.ijrobp.2018.05.032.Peer-Reviewed Original ResearchConceptsStereotactic body radiation therapyTumor hypoxic volumeHigh single dosesNon-small cell lung cancer (NSCLC) tumorsCell lung cancer tumorsLung cancer tumorsSingle dosesTumor hypoxiaTreatment failureNSCLC tumorsBlood ratioHypoxic volumeRadiation therapyDay 2F-fluoromisonidazole (FMISO) positron emission tomographyCancer tumorsInstitutional review board-approved studyTumor vascular responseBody radiation therapyBoard-approved studyConventional radiation therapyPositron emission tomographyBaseline hypoxiaDetectable hypoxiaNSCLC patients
2014
WE‐G‐BRD‐06: Variation in Dynamic Positron Emission Tomography Imaging of Tumor Hypoxia in Early Stage Non‐Small Cell Lung Cancer Patients Undergoing Stereotactic Body Radiotherapy
Kelada O, Decker R, Zheng M, Huang Y, Xia Y, Gallezot J, Liu C, Rockwell S, Carson R, Oelfke U, Carlson D. WE‐G‐BRD‐06: Variation in Dynamic Positron Emission Tomography Imaging of Tumor Hypoxia in Early Stage Non‐Small Cell Lung Cancer Patients Undergoing Stereotactic Body Radiotherapy. Medical Physics 2014, 41: 520-520. DOI: 10.1118/1.4889490.Peer-Reviewed Original ResearchNon-small cell lung cancer patientsCell lung cancer patientsPositron emission tomographyTumor hypoxic volumeLung cancer patientsCancer patientsHypoxic volumeEarly stage non-small cell lung cancer patientsTumor hypoxiaTumor vascular responseStereotactic body radiotherapyTotal tumor volumeNovel pilot studyEmission Tomography ImagingPositron emission tomography (PET) imagingDifferent time pointsTreatment failureFirst patientVascular responsesBody radiotherapyNSCLC tumorsTreatment individualizationBlood ratioTumor volumeSingle patient