2016
Age-related changes in binding of the D2/3 receptor radioligand [11C](+)PHNO in healthy volunteers
Matuskey D, Worhunksy P, Correa E, Pittman B, Gallezot JD, Nabulsi N, Ropchan J, Sreeram V, Gudepu R, Gaiser E, Cosgrove K, Ding YS, Potenza MN, Huang Y, Malison RT, Carson RE. Age-related changes in binding of the D2/3 receptor radioligand [11C](+)PHNO in healthy volunteers. NeuroImage 2016, 130: 241-247. PMID: 26876475, PMCID: PMC4808424, DOI: 10.1016/j.neuroimage.2016.02.002.Peer-Reviewed Original ResearchConceptsPositron emission tomographyReceptor availabilitySN/VTADopamine systemMidbrain regionsSubstantia nigra/ventral tegmental areaHealthy control subjectsWhole-brain voxel-wise analysisVentral tegmental areaPrevious imaging studiesVoxel-wise analysisAge-associated declineAge-related changesAntagonist radiotracersExtrastriatal areasReference tissue modelAgonist radiotracerAge-related declineControl subjectsTegmental areaHealthy subjectsHealthy volunteersPositive correlationReceptor radioligandSecondary analysis
2010
Reduced ventral striatal/ventral pallidal serotonin1B receptor binding potential in major depressive disorder
Murrough JW, Henry S, Hu J, Gallezot JD, Planeta-Wilson B, Neumaier JF, Neumeister A. Reduced ventral striatal/ventral pallidal serotonin1B receptor binding potential in major depressive disorder. Psychopharmacology 2010, 213: 547-553. PMID: 20480149, PMCID: PMC3139174, DOI: 10.1007/s00213-010-1881-0.Peer-Reviewed Original ResearchConceptsMajor depressive disorderMajor depressive episodeDepressive disorderPositron emission tomography scanningCurrent major depressive episodeHealthy control groupSpecific receptor subtypesHealthy control participantsHeteroreceptor functionMethodsTen participantsSerotonin1B receptorsAntidepressant actionΓ-amino butyric acidDepressive episodeGlutamate systemReceptor subtypesVentral pallidumNucleus accumbensDepressive phenotypeReceptor radioligandTherapeutic rationaleMDD groupControl groupDysfunctional rewardTomography scanning