2001
The Melanocortin-1 Receptor: Red Hair and Beyond
Schaffer J, Bolognia J. The Melanocortin-1 Receptor: Red Hair and Beyond. JAMA Dermatology 2001, 137: 1477-1485. PMID: 11708951, DOI: 10.1001/archderm.137.11.1477.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMelanocortin 1 receptorTransmembrane-spanning domainsG protein-coupled receptorsProtein-coupled receptorsRed hair phenotypeHuman pigmentationPigmentation phenotypesHair phenotypePheomelanin synthesisRed hairType of melaninHeterozygote effectUV-induced melanogenesisNonmelanoma skin cancerPhenotypeDecreased abilityReceptorsKey roleMelanocortin receptorsSkin cancerLociGeneticsFair skinPhysiologic variationsVariants
1999
UV Light and MSH Receptors
CHAKRABORTY A, FUNASAKA Y, SLOMINSKI A, BOLOGNIA J, SODI S, ICHIHASHI M, PAWELEK J. UV Light and MSH Receptors. Annals Of The New York Academy Of Sciences 1999, 885: 100-116. PMID: 10816644, DOI: 10.1111/j.1749-6632.1999.tb08668.x.Peer-Reviewed Original ResearchConceptsMSH receptorsSun-exposed areasAlpha-MSH receptorsSkin of miceMSH receptor activityPOMC-derived peptidesAction of UVBEffects of UVBGuinea pigsReceptor activityUVB irradiationUltraviolet B radiationReceptor productionCellular responsivenessReceptorsUVB damageB radiationSkin pigmentationUVBHuman melanocytesCutaneous melanogenesisMSHMelanin contentResultant increaseSkin