Jay Humphrey, PhD
John C. Malone Professor of Biomedical EngineeringCards
About
Research
Publications
2026
A mixed Cosserat and higher gradient formulation for fibrous tissues and biomaterials
Shirani M, Giorgio I, Astori D, Humphrey J. A mixed Cosserat and higher gradient formulation for fibrous tissues and biomaterials. International Journal Of Solids And Structures 2026, 324: 113671. DOI: 10.1016/j.ijsolstr.2025.113671.Peer-Reviewed Original ResearchCosserat effectsFibrous materialsHigher gradient theoriesBalance lawsRank-one convexityEngineering compositesCalculus of variationsPoynting effectGradient elasticityGradient theoryGradient formulationVirtual powerLinear formulationQuasi-convexBoundary conditionsComputational resultsCosseratBiological tissuesNon-classical effects
2025
Predicted Effects of Patient Variability and Notch Signaling on In Situ Vascular Tissue Engineering
van Asten J, Sahlgren C, Humphrey J, Ristori T, Loerakker S. Predicted Effects of Patient Variability and Notch Signaling on In Situ Vascular Tissue Engineering. Annals Of Biomedical Engineering 2025, 1-17. PMID: 41206426, DOI: 10.1007/s10439-025-03843-7.Peer-Reviewed Original ResearchImportance of localized dilatation and distensibility in identifying determinants of thoracic aortic aneurysm with neural operators
Li D, Goswami S, Cao Q, Oommen V, Assi R, Humphrey J, Karniadakis G. Importance of localized dilatation and distensibility in identifying determinants of thoracic aortic aneurysm with neural operators. PLOS Computational Biology 2025, 21: e1013550. PMID: 41066521, PMCID: PMC12520381, DOI: 10.1371/journal.pcbi.1013550.Peer-Reviewed Original ResearchConceptsData formatsNeural network modelInput data formatTraining dataThoracic aortic aneurysmNeural operationsSubject-specific informationNetwork modelPrediction errorArchitectureNetworkAortic aneurysmFull-field measurementsInformationFinite element frameworkRisk of dissectionTrainingPersonalized treatment strategiesElastic fiber integrityUNetThoracic aortopathyCombined insultElement frameworkTreatment strategiesDisease progressionMultiphysics Simulations of a Bioprinted Pulsatile Fontan Conduit.
Hu Z, Herrmann J, Schwarz E, Gerosa F, Emuna N, Humphrey J, Feinberg A, Hsia T, Skylar-Scott M, Marsden A. Multiphysics Simulations of a Bioprinted Pulsatile Fontan Conduit. Journal Of Biomechanical Engineering 2025, 147 PMID: 40172060, DOI: 10.1115/1.4068319.Peer-Reviewed Original ResearchConceptsSuperior vena cavaInferior vena cavaIncreased cardiac outputCardiac outputVena cavaElevated central venous pressureConduit performanceCongenital heart patientsCentral venous pressureDiminished cardiac outputFluid-structure interactionMultiphysics computational frameworkFontan surgeryFontan circulationFontan physiologyFontan conduitPalliative procedureLumped parameter networkPulmonary arteryCardiomyocyte contractilityValve placementMyocardial contractilityVenous pressureFontanVenous circulationUnderstanding and Reducing Cardiopulmonary Sequelae Associated With Chronic Hypoxia
Manning E, Ramachandra A, Sharma P, Nikola F, De Man R, Doddaballapur P, Raredon M, Szafron J, Baernthaler T, Justet A, Akingbesote N, Perry R, Adams T, Cavinato C, Yan X, Tellides G, Kaminski N, Humphrey J. Understanding and Reducing Cardiopulmonary Sequelae Associated With Chronic Hypoxia. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a3336-a3336. DOI: 10.1164/ajrccm.2025.211.abstracts.a3336.Peer-Reviewed Original ResearchThe Human Proximal Pulmonary Artery Plays a Critical Role in Regulating Cardiopulmonary Function in Health and Disease
Manning E, Lee S, Ashadujjaman M, De Man R, Cai Z, Adams T, Raredon M, Ramachandra A, Cavinato C, Heerdt P, Singh I, Choudhary G, Yan X, Bellini C, Tellides G, Humphrey J, Kaminski N. The Human Proximal Pulmonary Artery Plays a Critical Role in Regulating Cardiopulmonary Function in Health and Disease. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a2891-a2891. DOI: 10.1164/ajrccm.2025.211.abstracts.a2891.Peer-Reviewed Original ResearchConstrained optimization of scaffold behavior for improving tissue engineered vascular grafts
Hsu R, Szafron J, Carvalho C, Humphrey J, Marsden A. Constrained optimization of scaffold behavior for improving tissue engineered vascular grafts. Journal Of Biomechanics 2025, 186: 112670. PMID: 40286630, PMCID: PMC12085276, DOI: 10.1016/j.jbiomech.2025.112670.Peer-Reviewed Original ResearchConceptsTissue Engineered Vascular GraftsDesign parametersFunctions of native blood vesselsNative blood vesselsVascular graftsRelevant failure modesScaffold microstructureCompliance matchingMechanical behaviorBiodegradable scaffoldsLoad transferFailure modesExperimental testsOptimal designDegradation kineticsNumerical optimizationRemodeling outcomesConstrained optimizationVessel complianceDesignGraft remodelingFavorable characteristicsNeotissueIn silico frameworkParametersSustained tenascin-C expression drives neointimal hyperplasia and promotes aortocaval fistula failure
Gonzalez L, Zhang W, Bai H, Taniguchi R, Ramachandra A, Jovin D, Ohashi Y, Nguyen M, Thaxton C, Yatsula B, Vazquez-Padron R, Humphrey J, Martin K, Kyriakides T, Dardik A. Sustained tenascin-C expression drives neointimal hyperplasia and promotes aortocaval fistula failure. AJP Heart And Circulatory Physiology 2025, 328: h1147-h1167. PMID: 40247455, PMCID: PMC12150301, DOI: 10.1152/ajpheart.00661.2024.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArteriovenous Shunt, SurgicalDisease Models, AnimalGraft Occlusion, VascularHuman Umbilical Vein Endothelial CellsHumansHyperplasiaMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutMyocytes, Smooth MuscleNeointimaNF-kappa BTenascinThrombomodulinVascular PatencyVascular RemodelingVena Cava, InferiorConceptsArteriovenous fistula patencyTenascin-C expressionArteriovenous fistulaTissue factor expressionEnd-stage kidney diseaseAnti-inflammatory macrophage polarizationNeointimal hyperplasiaWT miceTenascin-CInflammatory microenvironmentWild-typeFactor expressionMacrophage polarizationArteriovenous fistula outcomesArteriovenous fistula failurePatent arteriovenous fistulaVein smooth muscle cellsArteriovenous fistula maturationSmooth muscle cellsOccluded arteriovenous fistulaHuman umbilical vein smooth muscle cellsImprove dialysis outcomesHuman umbilical vein endothelial cellsRegulation of inflammationNF-kB activationOversized Conduits Predict Stenosis in Tissue Engineered Vascular Grafts
Blum K, Turner M, Schwarz E, Best C, Kelly J, Yates A, Hor K, Matsuzaki Y, Drews J, Zakko J, Shah K, Shinoka T, Humphrey J, Marsden A, Breuer C. Oversized Conduits Predict Stenosis in Tissue Engineered Vascular Grafts. JACC Basic To Translational Science 2025, 10: 101248. PMID: 40243957, PMCID: PMC12434202, DOI: 10.1016/j.jacbts.2025.02.008.Peer-Reviewed Original ResearchTissue-engineered vascular graftsImplanting biodegradable scaffoldsWall shear stressComputational fluid dynamicsVascular graftsBiodegradable scaffoldsShear stressFluid dynamicsFlow patternsWeeks postimplantationAutologous cellsNondimensionalizationReducing stenosisTreat congenital heart diseaseComplex cardiac repairRecommendations for Design, Execution, and Reporting of Studies on Experimental Thoracic Aortopathy in Preclinical Models
Daugherty A, Milewicz D, Dichek D, Ghaghada K, Humphrey J, LeMaire S, Li Y, Mallat Z, Saeys Y, Sawada H, Shen Y, Suzuki T, Zhou Z, Dissections F. Recommendations for Design, Execution, and Reporting of Studies on Experimental Thoracic Aortopathy in Preclinical Models. Arteriosclerosis Thrombosis And Vascular Biology 2025, 45: 609-631. PMID: 40079138, PMCID: PMC12018150, DOI: 10.1161/atvbaha.124.320259.Peer-Reviewed Original Research