2023
Association of Kidney Tubule Biomarkers With Cardiac Structure and Function in the Multiethnic Study of Atherosclerosis
Wettersten N, Katz R, Greenberg J, Gutierrez O, Lima J, Sarnak M, Schrauben S, Deo R, Bonventre J, Vasan R, Kimmel P, Shlipak M, Ix J. Association of Kidney Tubule Biomarkers With Cardiac Structure and Function in the Multiethnic Study of Atherosclerosis. The American Journal Of Cardiology 2023, 196: 11-18. PMID: 37086700, PMCID: PMC10204591, DOI: 10.1016/j.amjcard.2023.02.031.Peer-Reviewed Original ResearchConceptsPlasma soluble urokinase plasminogen activator receptorSoluble urokinase plasminogen activator receptorKidney tubule injuryCardiac structural abnormalitiesUrokinase plasminogen activator receptorCardiovascular diseasePlasminogen activator receptorLower LVEFTubule injurySystemic inflammationVentricular mass/volume ratioStructural abnormalitiesChitinase-3-like protein 1Activator receptorTwofold greater concentrationCardiac magnetic resonance imagingKidney tubule healthChronic kidney diseaseIncident cardiovascular diseaseGlomerular filtration rateVentricular ejection fractionProtein 1Chemoattractant protein-1Multi-Ethnic StudyAlpha-1-microglobulin
2021
Urine Biomarkers of Kidney Tubule Health, Injury, and Inflammation are Associated with Progression of CKD in Children
Greenberg JH, Abraham AG, Xu Y, Schelling JR, Feldman HI, Sabbisetti VS, Ix JH, Jogalekar MP, Coca S, Waikar SS, Shlipak MG, Warady BA, Vasan RS, Kimmel PL, Bonventre JV, Denburg M, Parikh CR, Furth S, Consortium O. Urine Biomarkers of Kidney Tubule Health, Injury, and Inflammation are Associated with Progression of CKD in Children. Journal Of The American Society Of Nephrology 2021, 32: 2664-2677. PMID: 34544821, PMCID: PMC8722795, DOI: 10.1681/asn.2021010094.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAlbuminuriaAlpha-GlobulinsBiomarkersChemokine CCL2ChildChitinase-3-Like Protein 1CreatinineDisease ProgressionEpidermal Growth FactorFemaleFollow-Up StudiesGlomerular Filtration RateHepatitis A Virus Cellular Receptor 1HumansKidney TubulesMaleNephritisProspective StudiesRenal Insufficiency, ChronicConceptsUrine KIM-1CKD progressionUrine biomarkersMicroglobulin concentrationsHighest quartileKIM-1MCP-1High riskRapid kidney function declineBiomarker concentrationsEGF concentrationsKidney tubule healthNovel urine biomarkersUrine biomarker concentrationsKidney function declineProgression of CKDUrine creatinine concentrationIdentification of childrenTubular healthMultivariable adjustmentComposite outcomeTubular injuryPrimary outcomeFunction declineStudy enrollmentLong-Term Kidney Outcomes Following Dialysis-Treated Childhood Acute Kidney Injury: A Population-Based Cohort Study
Robinson CH, Jeyakumar N, Luo B, Wald R, Garg AX, Nash DM, McArthur E, Greenberg J, Askenazi D, Mammen C, Thabane L, Goldstein S, Parekh RS, Zappitelli M, Chanchlani R. Long-Term Kidney Outcomes Following Dialysis-Treated Childhood Acute Kidney Injury: A Population-Based Cohort Study. Journal Of The American Society Of Nephrology 2021, 32: 2005-2019. PMID: 34039667, PMCID: PMC8455253, DOI: 10.1681/asn.2020111665.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdolescentCase-Control StudiesChildChild, PreschoolFemaleFollow-Up StudiesHumansHypertensionIncidenceInfantInfant, NewbornKidney Failure, ChronicMaleMortalityOntarioProportional Hazards ModelsRenal DialysisRenal Insufficiency, ChronicRetrospective StudiesRisk FactorsSurvivorsTime FactorsConceptsAKI survivorsKidney failureLong-term riskCohort studyCox proportional hazards regression analysisAdverse short-term outcomesChildhood acute kidney injuryProportional hazards regression analysisHigher long-term riskAcute kidney injuryHealth administrative databasesRetrospective cohort studyHazards regression analysisShort-term outcomesLong-term outcomesBasis of ageAKI episodesPediatric AKISubsequent AKIKidney injuryComposite outcomeCardiac surgeryHospitalized cohortMechanical ventilationPediatric hospitalizations