Featured Publications
Reward-Mediated, Model-Free Reinforcement-Learning Mechanisms in Pavlovian and Instrumental Tasks Are Related
Afshar N, Cinotti F, Martin D, Khamassi M, Calu DJ, Taylor JR, Groman SM. Reward-Mediated, Model-Free Reinforcement-Learning Mechanisms in Pavlovian and Instrumental Tasks Are Related. Journal Of Neuroscience 2022, 43: 458-471. PMID: 36216504, PMCID: PMC9864557, DOI: 10.1523/jneurosci.1113-22.2022.Peer-Reviewed Original ResearchConceptsGoal-tracking behaviorReinforcement learning mechanismInstrumental learning processesSign-tracking behaviorModel-free reinforcementApproach taskInstrumental taskInstrumental behaviorBehavioral proceduresSubjects designLearning mechanismDecision Making TaskModel-based computationLearning processModel-free reinforcement learningPredictive cuesIncentive salienceAssociative learningIndividual differencesComputational mechanismsDecision-making processPavlovianModel-based algorithmValue representationAction valuesIntroducing the PLOS ONE Collection on the neuroscience of reward and decision making
Groman SM, Ikemoto S, Rushworth M, Taylor JR, Whelan R. Introducing the PLOS ONE Collection on the neuroscience of reward and decision making. PLOS ONE 2020, 15: e0240505. PMID: 33031482, PMCID: PMC7544023, DOI: 10.1371/journal.pone.0240505.Peer-Reviewed Original ResearchConceptsAction-outcome associationsDecision-making deficitsPast experienceDecision makingNeuroscience techniquesNeurobiological mechanismsBehavioral approachNovel inferencesAdaptive decisionDecision-making functionsMechanistic linkParticular actionNeuroscienceAlternative outcomesBiological mechanismsOrganismsComputational functionsRewardNew insightsParticular outcomeNew environmentRecent advancesPredatorsMakingBiology
2009
Neuronal Correlates of Instrumental Learning in the Dorsal Striatum
Kimchi EY, Torregrossa MM, Taylor JR, Laubach M. Neuronal Correlates of Instrumental Learning in the Dorsal Striatum. Journal Of Neurophysiology 2009, 102: 475-489. PMID: 19439679, PMCID: PMC2712266, DOI: 10.1152/jn.00262.2009.Peer-Reviewed Original ResearchConceptsDorsal striatumResponse portsNeuronal activityTask-related firingTask-related neuronsMovement-related potentialsInitiation of movementLateral striatumLearning-related changesMedial striatumStriatumNeuronal correlatesReward portNumber of neuronsAcoustic stimuliNeuronsOperant taskField potentialsProgressive increaseLateral regionsTheta-band oscillationsHigh rateTraining periodInstrumental learningHead entries
2000
Role for dopamine in the behavioral functions of the prefrontal corticostriatal system: implications for mental disorders and psychotropic drug action
Jentsch J, Roth R, Taylor J. Role for dopamine in the behavioral functions of the prefrontal corticostriatal system: implications for mental disorders and psychotropic drug action. Progress In Brain Research 2000, 126: 433-453. PMID: 11105661, DOI: 10.1016/s0079-6123(00)26028-7.Peer-Reviewed Original ResearchMeSH KeywordsAmphetaminesAmygdalaAnimalsBehaviorBrain MappingCentral Nervous System StimulantsCognitionCorpus StriatumDepressionDopamineDopamine AgonistsEmotionsHaplorhiniHumansLearningLimbic SystemMammalsMemoryMental DisordersNeural PathwaysNeurotransmitter AgentsNucleus AccumbensPhencyclidinePrefrontal CortexPsychotropic DrugsReceptors, NeurotransmitterRewardSchizophreniaSubstance-Related DisordersConceptsForebrain sitesPsychotropic drug actionPrecise anatomical sitesRole of dopamineDopaminergic dysfunctionDopaminergic transmissionDopaminergic functionDopamine neuronsDopaminergic responseReward-related stimuliCorticolimbic circuitsChronic activationDopaminergic activationStriatal regionsAfferent controlAnatomical sitesCorticostriatal systemMental disordersNeuropsychiatric disordersNeuromodulatory systemsPersistent neuroadaptationsDrug actionBehavioral functionsCellular mechanismsDopamine
1999
Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli
Jentsch J, Taylor J. Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli. Psychopharmacology 1999, 146: 373-390. PMID: 10550488, DOI: 10.1007/pl00005483.Peer-Reviewed Original ResearchConceptsControl of behaviorInhibitory controlIncentive learning processesDrug abuseInhibitory response controlReward-related stimuliDrug-seeking behaviorChronic drug useCognitive impulsivityMotivational processesRelated stimuliMotivational qualitiesFrontostriatal systemFrontostriatal dysfunctionDrug seekingDrugs of abuseNeuro-anatomicalVentral striatumDrive stateAllocation of behaviorAppropriate behavioral patternsCognitive dysfunctionResponse controlFrontal cortexPrimate brainEnhancement of Locomotor Activity and Conditioned Reward to Cocaine by Brain-Derived Neurotrophic Factor
Horger B, Iyasere C, Berhow M, Messer C, Nestler E, Taylor J. Enhancement of Locomotor Activity and Conditioned Reward to Cocaine by Brain-Derived Neurotrophic Factor. Journal Of Neuroscience 1999, 19: 4110-4122. PMID: 10234039, PMCID: PMC6782687, DOI: 10.1523/jneurosci.19-10-04110.1999.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorDevelopment of sensitizationLocomotor sensitizationBDNF infusionNeurotrophic factorNucleus accumbensStimulant effectsInitial stimulant effectMesolimbic DA systemCocaine-induced locomotionVentral tegmental areaMesolimbic dopamine systemWild-type littermatesPsychomotor stimulant effectsBDNF administrationDopaminergic neuronsTegmental areaCocaine injectionCocaine dosesControl animalsDopamine systemLocomotor activityDrug rewardCR leverDA systemEnhanced responding for conditioned reward produced by intra-accumbens amphetamine is potentiated after cocaine sensitization
Taylor J, Horger B. Enhanced responding for conditioned reward produced by intra-accumbens amphetamine is potentiated after cocaine sensitization. Psychopharmacology 1999, 142: 31-40. PMID: 10102780, DOI: 10.1007/s002130050859.Peer-Reviewed Original ResearchConceptsIntra-accumbens amphetamineIntra-NAc amphetamineCocaine sensitizationLocomotor sensitizationNucleus accumbensCR leverLong-term neuronal adaptationsSaline-treated groupMesolimbic dopamine systemStimulant drug useSaline infusionSaline injectionDopamine systemPsychomotor stimulantsDrug useNeuronal adaptationConditioned rewardStimulant drugsAmphetaminePrior exposureSensitizationTest daySeparate groupsNCR leverPredictive associations
1991
Potentiation of the effects of reward-related stimuli by dopaminergic-dependent mechanisms in the nucleus accumbens
Cador M, Taylor J, Robbins T. Potentiation of the effects of reward-related stimuli by dopaminergic-dependent mechanisms in the nucleus accumbens. Psychopharmacology 1991, 104: 377-385. PMID: 1924645, DOI: 10.1007/bf02246039.Peer-Reviewed Original ResearchConceptsDorsal noradrenergic bundleDose-dependent increaseDA-dependent mechanismSignificant dose-dependent increaseSmaller infusion volumesDA infusionDA receptorsAlpha-flupenthixolNoradrenergic bundleSystemic doseProfound depletionNucleus accumbensReward-related processesInfusion volumeNeurotoxic lesionsNA levelsNeurochemical mediationNoradrenalinePotentiationCONDITIONED REINFORCEMENTDopamineReward-related stimuliConditioned reinforcersAmphetamineDoses
1989
Limbic-striatal interactions in reward-related processes
Robbins T, Cador M, Taylor J, Everitt B. Limbic-striatal interactions in reward-related processes. Neuroscience & Biobehavioral Reviews 1989, 13: 155-162. PMID: 2682402, DOI: 10.1016/s0149-7634(89)80025-9.Peer-Reviewed Original ResearchConceptsVentral striatumDA depletionIndirect dopamine agonist d-amphetamineStriatal DA depletionReward-related stimuliAgonist d-amphetamineSelective stimulatory effectDA-dependent processesBasolateral nucleusD-amphetamineExcitotoxic lesionsReward-related processesSecond-order scheduleDorsal striatumStriatumAmygdala lesionsStimulatory effectLesionsSimilar discriminative propertiesDiscriminative propertiesOrder schedulePredictive associationsSexual reinforcementDorsalParallel findings
1986
6-Hydroxydopamine lesions of the nucleus accumbens, but not of the caudate nucleus, attenuate enhanced responding with reward-related stimuli produced by intra-accumbens d-amphetamine
Taylor J, Robbins T. 6-Hydroxydopamine lesions of the nucleus accumbens, but not of the caudate nucleus, attenuate enhanced responding with reward-related stimuli produced by intra-accumbens d-amphetamine. Psychopharmacology 1986, 90: 390-397. PMID: 3097729, DOI: 10.1007/bf00179197.Peer-Reviewed Original Research