2023
Modeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis
Jourdon A, Wu F, Mariani J, Capauto D, Norton S, Tomasini L, Amiri A, Suvakov M, Schreiner J, Jang Y, Panda A, Nguyen C, Cummings E, Han G, Powell K, Szekely A, McPartland J, Pelphrey K, Chawarska K, Ventola P, Abyzov A, Vaccarino F. Modeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis. Nature Neuroscience 2023, 26: 1505-1515. PMID: 37563294, PMCID: PMC10573709, DOI: 10.1038/s41593-023-01399-0.Peer-Reviewed Original ResearchConceptsIdiopathic autism spectrum disorderCortical neuron subtypesAutism spectrum disorderEarly cortical developmentCortical organoidsCortical plateExcitatory neuronsCortical developmentRare formNeuron subtypesUnaffected fatherASD pathogenesisForebrain organoidsEarly neurogenesisRare variantsIdiopathic autismRisk genesTranscriptomic alterationsNeuronsProbandsSingle-cell transcriptomicsForebrain developmentSpectrum disorderTranscriptomic changesAlterations
2004
Young children with autism show atypical brain responses to fearful versus neutral facial expressions of emotion
Dawson G, Webb SJ, Carver L, Panagiotides H, McPartland J. Young children with autism show atypical brain responses to fearful versus neutral facial expressions of emotion. Developmental Science 2004, 7: 340-359. PMID: 15595374, DOI: 10.1111/j.1467-7687.2004.00352.x.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderEvent-related potentialsNegative slow waveNeutral facial expressionsNeutral facesEmotion perceptionBrain responsesFacial expressionsChronological age-matched childrenHigh-density event-related potentialsLarger negative slow waveImpaired emotion perceptionAtypical brain responsesDifferential brain activityEarly ERP componentsDifferential brain responsesEarly negative componentFear facesEmotional stimuliAge-matched childrenDifferent emotionsERP componentsFear expressionSocial attentionTypical development