2019
Randomized, Sham-Controlled Trial of Real-Time Functional Magnetic Resonance Imaging Neurofeedback for Tics in Adolescents With Tourette Syndrome
Sukhodolsky DG, Walsh C, Koller WN, Eilbott J, Rance M, Fulbright RK, Zhao Z, Bloch MH, King R, Leckman JF, Scheinost D, Pittman B, Hampson M. Randomized, Sham-Controlled Trial of Real-Time Functional Magnetic Resonance Imaging Neurofeedback for Tics in Adolescents With Tourette Syndrome. Biological Psychiatry 2019, 87: 1063-1070. PMID: 31668476, PMCID: PMC7015800, DOI: 10.1016/j.biopsych.2019.07.035.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCross-Over StudiesHumansMagnetic Resonance ImagingNeurofeedbackSeverity of Illness IndexTicsTourette SyndromeConceptsSupplementary motor areaYale Global Tic Severity ScaleFunctional magnetic resonanceTic Severity ScaleReal-time functional magnetic resonanceTourette syndromeSeverity ScaleYale Global Tic Severity Scale-Total Tic ScoreTotal tic scorePrimary outcome measureSham control conditionReduction of ticsMagnetic resonanceSecondary outcomesSessions of neurofeedbackCrossover studyTic symptomsTic scoreOutcome measuresMotor areaSecondary measuresTic severityReal neurofeedbackEnd pointNeurofeedback intervention
2016
Intranasal Oxytocin Enhances Connectivity in the Neural Circuitry Supporting Social Motivation and Social Perception in Children with Autism
Gordon I, Jack A, Pretzsch CM, Vander Wyk B, Leckman JF, Feldman R, Pelphrey KA. Intranasal Oxytocin Enhances Connectivity in the Neural Circuitry Supporting Social Motivation and Social Perception in Children with Autism. Scientific Reports 2016, 6: 35054. PMID: 27845765, PMCID: PMC5109935, DOI: 10.1038/srep35054.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderIntranasal oxytocinSocial motivationSocial perceptionSocial-emotional informationFunctional magnetic resonance imagingPlacebo-controlled crossover designBiological motionSocial stimuliAngry voicesSocial deficitsSpectrum disorderOT administrationMesolimbic reward pathwayBehavioral treatmentBrain rewardReduced connectivityBrain regionsReward pathwayCortical sitesRewardPerceptionMotivationOxytocinBrain sites
2014
Neural plasticity in fathers of human infants
Kim P, Rigo P, Mayes LC, Feldman R, Leckman JF, Swain JE. Neural plasticity in fathers of human infants. Social Neuroscience 2014, 9: 522-535. PMID: 24958358, PMCID: PMC4144350, DOI: 10.1080/17470919.2014.933713.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainDepressionFathersGray MatterHumansImage Processing, Computer-AssistedLongitudinal StudiesMagnetic Resonance ImagingMaleNeuronal PlasticityOrgan SizeParentingTime FactorsConceptsFathers' brainsNeural plasticityLateral prefrontal cortexCurrent longitudinal studyPosterior cingulate cortexVoxel-based morphometry analysisGray matter volumeNeural basisCognitive developmentNeural regionsNeural changesOrbitofrontal cortexPrefrontal cortexWeeks postpartumHuman fathersParental motivationCingulate cortexHuman infantsMood symptomsBrain regionsLongitudinal studyPostpartum mood symptomsMatter volumeMorphometry analysisHuman mothers
2013
Oxytocin enhances brain function in children with autism
Gordon I, Vander Wyk B, Bennett RH, Cordeaux C, Lucas MV, Eilbott JA, Zagoory-Sharon O, Leckman JF, Feldman R, Pelphrey KA. Oxytocin enhances brain function in children with autism. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 20953-20958. PMID: 24297883, PMCID: PMC3876263, DOI: 10.1073/pnas.1312857110.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, IntranasalAdolescentAmygdalaChildChild Development Disorders, PervasiveFemaleFrontal LobeHumansJudgmentMagnetic Resonance ImagingMaleOxytocinSalivaSocial AdjustmentConceptsAutism spectrum disorderSuperior temporal sulcusTemporal sulcusOrbitofrontal cortexLeft superior temporal sulcusMiddle frontal gyrusMedial prefrontal cortexRight orbitofrontal cortexSocial attunementSocial judgmentsMeaningful stimuliFrontal gyrusSpectrum disorderBrain activityPrefrontal cortexRight amygdalaSocial functioningFunctional MRIPremotor cortexHedonic evaluationBrain functionJudgmentsCortexChildrenOxytocinBrain mechanisms for prepulse inhibition in adults with Tourette syndrome: Initial findings
Zebardast N, Crowley MJ, Bloch MH, Mayes LC, Wyk BV, Leckman JF, Pelphrey KA, Swain JE. Brain mechanisms for prepulse inhibition in adults with Tourette syndrome: Initial findings. Psychiatry Research 2013, 214: 33-41. PMID: 23916249, PMCID: PMC3932431, DOI: 10.1016/j.pscychresns.2013.05.009.Peer-Reviewed Original ResearchConceptsTourette syndromeFunctional magnetic resonance imagingHealthy subjectsTic severityWhole-brain functional magnetic resonance imagingYale Global Tic Severity ScaleTactile startle responseCase-control study designTic Severity ScaleCortical-striatal circuitsBrain activityMagnetic resonance imagingMultiple brain regionsLeft middle frontal gyrusMiddle frontal gyrusDegree of PPIPulse-alone stimuliBlock-design fMRI paradigmTic symptomsNeuropathological dataHealthy controlsPrepulse inhibitionDevelopmental neuropsychiatric disordersSensorimotor gatingLeft caudate
2011
Breastfeeding, brain activation to own infant cry, and maternal sensitivity
Kim P, Feldman R, Mayes LC, Eicher V, Thompson N, Leckman JF, Swain JE. Breastfeeding, brain activation to own infant cry, and maternal sensitivity. Journal Of Child Psychology And Psychiatry 2011, 52: 907-915. PMID: 21501165, PMCID: PMC3134570, DOI: 10.1111/j.1469-7610.2011.02406.x.Peer-Reviewed Original ResearchConceptsFormula-feeding mothersFirst postpartum monthSuperior frontal gyrusEarly postpartumMonths postpartumPostpartum monthsBrain activationBrain regionsMaternal sensitivityFrontal gyrusMaternal behaviorMaternal brain activationMaternal brain responsesRight superior frontal gyrusMagnetic resonance imaging studyGreater activationMaternal-infant bondingRecent functional magnetic resonance imaging (fMRI) studiesResonance imaging studyFunctional magnetic resonance imaging studyMother-infant contactHealthy infantsWeeks postpartumGreater maternal sensitivityHigher maternal sensitivityBiofeedback of Real-Time Functional Magnetic Resonance Imaging Data from the Supplementary Motor Area Reduces Functional Connectivity to Subcortical Regions
Hampson M, Scheinost D, Qiu M, Bhawnani J, Lacadie CM, Leckman JF, Constable RT, Papademetris X. Biofeedback of Real-Time Functional Magnetic Resonance Imaging Data from the Supplementary Motor Area Reduces Functional Connectivity to Subcortical Regions. Brain Connectivity 2011, 1: 91-98. PMID: 22432958, PMCID: PMC3621512, DOI: 10.1089/brain.2011.0002.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiofeedback, PsychologyComputer SystemsFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMotor CortexNerve NetNeural PathwaysPhotic StimulationYoung AdultConceptsSupplementary motor areaReal-time functional magnetic resonanceFunctional connectivityTourette syndromeFunctional magnetic resonanceMotor areaSubcortical regionsBiofeedback sessionsState functional connectivityTic symptomsMagnetic resonance imaging dataHealthy subjectsTS patientsMagnetic resonanceBrain areasBiofeedbackFunctional magnetic resonance imaging (fMRI) dataFurther studiesSignificant increaseAberrant dynamicsSubjectsRecent studiesImaging dataSessionsPatients
2010
The Plasticity of Human Maternal Brain: Longitudinal Changes in Brain Anatomy During the Early Postpartum Period
Kim P, Leckman JF, Mayes LC, Feldman R, Wang X, Swain JE. The Plasticity of Human Maternal Brain: Longitudinal Changes in Brain Anatomy During the Early Postpartum Period. Behavioral Neuroscience 2010, 124: 695-700. PMID: 20939669, PMCID: PMC4318549, DOI: 10.1037/a0020884.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainFemaleHumansMagnetic Resonance ImagingMaternal BehaviorNerve Fibers, UnmyelinatedNeuronal PlasticityPostpartum PeriodConceptsGray matter volumeEarly postpartum periodMatter volumeMaternal brainPostpartum periodParietal lobePrefrontal cortexTime pointsGray matter changesProspective longitudinal studyVoxel-based morphometryMother's brainSubstantia nigraMonths postpartumWeeks postpartumMidbrain areaMatter changesAnimal studiesMaternal motivationBrain regionsLongitudinal changesFirst monthMagnetic resonance imagesHigh-resolution magnetic resonance imagesMaternal behaviorPerceived quality of maternal care in childhood and structure and function of mothers' brain
Kim P, Leckman JF, Mayes LC, Newman M, Feldman R, Swain JE. Perceived quality of maternal care in childhood and structure and function of mothers' brain. Developmental Science 2010, 13: 662-673. PMID: 20590729, PMCID: PMC3974609, DOI: 10.1111/j.1467-7687.2009.00923.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainBrain MappingCryingFemaleHumansInfant, NewbornMagnetic Resonance ImagingMaternal AgeMaternal BehaviorMiddle AgedSurveys and QuestionnairesYoung AdultConceptsMiddle frontal gyrusSuperior temporal gyrusMaternal careTemporal gyrusHuman mothersFrontal gyrusInfant stimuliFusiform gyrusFirst postpartum monthLarger gray matter volumeGray matter volumeMagnetic resonance imagingHigh maternal careLow maternal careMother's brainPostpartum monthsLong-term effectsOrbital gyrusAnimal studiesBrain areasMatter volumeNeglectful motheringResonance imagingBrain regionsHeightened stress reactivity
2008
Brain Areas Coactivating with Motor Cortex During Chronic Motor Tics and Intentional Movements
Hampson M, Tokoglu F, King RA, Constable RT, Leckman JF. Brain Areas Coactivating with Motor Cortex During Chronic Motor Tics and Intentional Movements. Biological Psychiatry 2008, 65: 594-599. PMID: 19111281, PMCID: PMC2679868, DOI: 10.1016/j.biopsych.2008.11.012.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainFemaleHumansIntentionMagnetic Resonance ImagingMaleMotor CortexMovementTic DisordersTourette SyndromeConceptsMotor cortexSupplementary motor areaControl subjectsBrain areasMotor ticsTic disordersTic movementsMotor areaTic-like movementsHealthy control subjectsChronic tic disorderNormal control subjectsChronic motor ticsNovel intervention strategiesFunctional neuroimaging studiesTic executionSevere ticsIntentional movementPatient's ticsMotor regionsPremonitory urgesBrain activity patternsAdult subjectsTic generationCortex
2007
The role of abnormal neural oscillations in the pathophysiology of co-occurring Tourette syndrome and attention-deficit/hyperactivity disorder
Sukhodolsky DG, Leckman JF, Rothenberger A, Scahill L. The role of abnormal neural oscillations in the pathophysiology of co-occurring Tourette syndrome and attention-deficit/hyperactivity disorder. European Child & Adolescent Psychiatry 2007, 16: 51-59. PMID: 17665283, DOI: 10.1007/s00787-007-1007-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAttention Deficit Disorder with HyperactivityBrainComorbidityHumansMagnetic Resonance ImagingNeuronsPeriodicityPositron-Emission TomographyTourette SyndromeConceptsAttention-deficit/hyperactivity disorderTourette syndromeAbnormal neural oscillationsOscillatory activityHyperactivity disorderAbnormal oscillatory activityThalamo-cortical circuitsSymptoms of ADHDNeural oscillationsNeural oscillatory activityBasal gangliaFunctional abnormalitiesNormal brainThalamocortical regionsThalamocortical oscillationsCortical regionsTransient hyperpolarizationPrefrontal cortexNeural activityNeural communicationPathophysiologyMotor controlSyndromeBrainDisorders
2005
Caudate volumes in childhood predict symptom severity in adults with Tourette syndrome
Bloch MH, Leckman JF, Zhu H, Peterson BS. Caudate volumes in childhood predict symptom severity in adults with Tourette syndrome. Neurology 2005, 65: 1253-1258. PMID: 16247053, PMCID: PMC2367161, DOI: 10.1212/01.wnl.0000180957.98702.69.Peer-Reviewed Original ResearchConceptsSeverity of ticsBasal ganglia volumesCaudate nucleus volumeTourette syndromeObsessive-compulsive symptomsGanglia volumesEarly adulthoodObsessive-compulsive disorderTic symptomsCaudate nucleusCaudate volumeCross-sectional imaging studiesThalamo-cortical circuitsNucleus volumeSeverity of symptomsAge 16 yearsProspective longitudinal studyAge 14 yearsClinical statusClinical assessmentClinical measuresMorphologic disturbancesMRI scansSymptomsImaging studies
2004
Altered Interhemispheric Connectivity in Individuals With Tourettes Disorder
Plessen KJ, Wentzel-Larsen T, Hugdahl K, Feineigle P, Klein J, Staib LH, Leckman JF, Bansal R, Peterson BS. Altered Interhemispheric Connectivity in Individuals With Tourettes Disorder. American Journal Of Psychiatry 2004, 161: 2028-2037. PMID: 15514403, DOI: 10.1176/appi.ajp.161.11.2028.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAttention Deficit Disorder with HyperactivityCase-Control StudiesCerebral CortexComorbidityCorpus CallosumCross-Sectional StudiesFunctional LateralityHumansMagnetic Resonance ImagingMaleNeuronal PlasticityObsessive-Compulsive DisorderPrefrontal CortexSeverity of Illness IndexTourette SyndromeConceptsCorpus callosum sizeCallosum sizeTourette's disorderCorpus callosumCerebral hemispheresComparison subjectsCross-sectional case-control studyMidsagittal corpus callosum areaCorpus callosum areaCase-control studyEffects of medicationAge 30 yearsCortical inhibitory interneuronsHigh-resolution magnetic resonanceHealthy comparison subjectsMajor commissureComorbid illnessesTic symptomsOrbitofrontal cortical volumeCortical volumeInhibitory interneuronsInterhemispheric connectivityInhibitory inputsTic severityPrior evidence
2003
Basal Ganglia Volumes in Patients With Gilles de la Tourette Syndrome
Peterson BS, Thomas P, Kane MJ, Scahill L, Zhang H, Bronen R, King RA, Leckman JF, Staib L. Basal Ganglia Volumes in Patients With Gilles de la Tourette Syndrome. JAMA Psychiatry 2003, 60: 415-424. PMID: 12695320, DOI: 10.1001/archpsyc.60.4.415.Peer-Reviewed Original ResearchConceptsBasal ganglia volumesBasal gangliaCaudate nucleus volumeTourette syndromeGanglia volumesObsessive-compulsive disorderLenticular nucleus volumesTic symptomsNucleus volumeGilles dePathophysiology of TSPrior neuroleptic exposureHealthy control subjectsSeverity of ticsComorbid obsessive-compulsive disorderGreat clinical relevanceAttention-deficit/hyperactivity disorder (ADHD) symptomsHyperactivity disorder symptomsRepeated-measures analysisNeuroleptic exposureControl subjectsFunctional disturbancesTrait abnormalityClinical relevanceGanglia
2001
Regional Brain and Ventricular Volumes in Tourette Syndrome
Peterson BS, Staib L, Scahill L, Zhang H, Anderson C, Leckman JF, Cohen DJ, Gore JC, Albert J, Webster R. Regional Brain and Ventricular Volumes in Tourette Syndrome. JAMA Psychiatry 2001, 58: 427-440. PMID: 11343521, DOI: 10.1001/archpsyc.58.5.427.Peer-Reviewed Original ResearchConceptsParieto-occipital regionsTourette syndromeTic symptomsCerebral volumeVentricular volumePathophysiology of TST subjectsWhite matter portionsThalamo-cortical circuitrySignificant inverse associationRegional cerebral volumesHigh-resolution anatomical magnetic resonance imagesStandard anatomical landmarksSex differencesAge-related findingsDorsal prefrontal regionsRegional brainCortico-striatoHealthy childrenHealthy controlsInverse associationHealthy subjectsOccipital volumeTS groupCortical regions
2000
Preliminary Findings of Antistreptococcal Antibody Titers and Basal Ganglia Volumes in Tic, Obsessive-compulsive, and Attention-Deficit/Hyperactivity Disorders
Peterson BS, Leckman JF, Tucker D, Scahill L, Staib L, Zhang H, King R, Cohen DJ, Gore JC, Lombroso P. Preliminary Findings of Antistreptococcal Antibody Titers and Basal Ganglia Volumes in Tic, Obsessive-compulsive, and Attention-Deficit/Hyperactivity Disorders. JAMA Psychiatry 2000, 57: 364-372. PMID: 10768698, DOI: 10.1001/archpsyc.57.4.364.Peer-Reviewed Original ResearchConceptsBasal ganglia volumesAttention-deficit/hyperactivity disorderAntistreptococcal antibody titersObsessive-compulsive disorderAntibody titersGanglia volumesStreptococcal infectionAntistreptococcal antibodiesPreliminary serological evidencePrior streptococcal infectionRecurrent streptococcal infectionsHyperactivity disorderPresence of ADHDBasal ganglia nucleiHigh antibody titersGlobus pallidus nucleusDSM-IV diagnosisStreptococcal exposurePallidus nucleusAntistreptolysin OOCD comorbiditySerological evidenceSusceptible personsTic disordersDiagnostic comorbidity
1998
A Functional Magnetic Resonance Imaging Study of Tic Suppression in Tourette Syndrome
Peterson BS, Skudlarski P, Anderson AW, Zhang H, Gatenby JC, Lacadie CM, Leckman JF, Gore JC. A Functional Magnetic Resonance Imaging Study of Tic Suppression in Tourette Syndrome. JAMA Psychiatry 1998, 55: 326-333. PMID: 9554428, DOI: 10.1001/archpsyc.55.4.326.Peer-Reviewed Original ResearchConceptsTic suppressionTourette syndromeTic symptomsBasal gangliaPathogenesis of ticsVoluntary tic suppressionMagnetic resonance imaging studyResonance imaging studyFunctional magnetic resonance imaging studySubcortical neural circuitsFunctional magnetic resonance imagingMagnetic resonance imagingConnected cortical regionsRegional signal changesImpaired modulationSignal changesFunctional debilityNeuronal activityResonance imagingAdult subjectsImaging studiesCortical regionsNeuropsychiatric disordersNeural circuitsSyndrome
1993
Severe disturbances in speech, swallowing, and gait following stereotactic infrathalamic lesions in Gilles de la Tourette's syndrome.
Leckman JF, de Lotbinière A, Marek K, Gracco C, Scahill L, Cohen DJ. Severe disturbances in speech, swallowing, and gait following stereotactic infrathalamic lesions in Gilles de la Tourette's syndrome. Neurology 1993, 43: 890-4. PMID: 8492943, DOI: 10.1212/wnl.43.5.890.Peer-Reviewed Original ResearchMeSH KeywordsAdultDeglutition DisordersGaitHumansMagnetic Resonance ImagingMaleMotor ActivityPostoperative ComplicationsSpeech DisordersStereotaxic TechniquesThalamusTourette SyndromeConceptsGilles de la Tourette's syndromeLa Tourette's syndromeLow-density areasMotor ticsTourette syndromeLast surgical procedureSevere gait disturbanceAnterior cingulate gyrusBilateral anterior cingulotomyGait disturbanceNeurologic deficitsObsessive-compulsive disorderSwallowing disordersAnterior cingulotomyPhonic ticsPostural instabilitySurgical proceduresCingulate gyrusObsessive-compulsive symptomsSyndromeNeurosurgical proceduresPatient's speechPatientsLesionsSecond procedureReduced basal ganglia volumes in Tourette's syndrome using three-dimensional reconstruction techniques from magnetic resonance images.
Peterson B, Riddle MA, Cohen DJ, Katz LD, Smith JC, Hardin MT, Leckman JF. Reduced basal ganglia volumes in Tourette's syndrome using three-dimensional reconstruction techniques from magnetic resonance images. Neurology 1993, 43: 941-9. PMID: 8492950, DOI: 10.1212/wnl.43.5.941.Peer-Reviewed Original ResearchMeSH KeywordsAdultBasal GangliaBrainFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedReference ValuesTourette SyndromeConceptsBasal gangliaSyndrome patientsNormal controlsReduced basal ganglia volumeBasal ganglia volumesTourette syndrome patientsGlobus pallidus nucleusSmaller mean volumesPathogenesis of TSEsNeuroleptic exposureGanglia volumesPallidus nucleusNeuroradiologic studiesTourette syndromeVolumetric asymmetryMean volumeMagnetic resonance imagesGangliaAxial imagesSocioeconomic statusAsymmetry indexSyndromeResonance imagesVolume reductionMR scanner