2018
Incremental value of DNA analysis in pancreatic cysts stratified by clinical risk factors
Farrell J, Al-Haddad M, Jackson SA, Gonda T. Incremental value of DNA analysis in pancreatic cysts stratified by clinical risk factors. Gastrointestinal Endoscopy 2018, 89: 832-841.e2. PMID: 30447214, DOI: 10.1016/j.gie.2018.10.049.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaCyst FluidDNAEndoscopic Ultrasound-Guided Fine Needle AspirationFollow-Up StudiesGenes, Tumor SuppressorHumansKaplan-Meier EstimateLoss of HeterozygosityMutationPancreatic CystPancreatic NeoplasmsProportional Hazards ModelsProto-Oncogene Proteins p21(ras)Retrospective StudiesRisk AssessmentRisk FactorsSequence Analysis, DNASurvival AnalysisConceptsHigh-risk stigmataWorrisome featuresMalignancy riskPatient outcomesDNA abnormalitiesPredictive valueCyst fluid molecular analysisLong-term malignancy riskClinical risk factorsIncremental predictive valueCytologic malignancyClinical characteristicsFinal pathologyFree survivalSuch patientsPatient populationPancreatic cystsRisk factorsMalignant outcomeCyst fluidKras mutationsPatientsSurvival analysisAbnormalitiesTumor suppressor gene
2014
Chronic pancreatitis, a comprehensive review and update. Part I: Epidemiology, etiology, risk factors, genetics, pathophysiology, and clinical features
Muniraj T, Aslanian HR, Farrell J, Jamidar PA. Chronic pancreatitis, a comprehensive review and update. Part I: Epidemiology, etiology, risk factors, genetics, pathophysiology, and clinical features. Disease-a-Month 2014, 60: 530-550. PMID: 25510320, DOI: 10.1016/j.disamonth.2014.11.002.Peer-Reviewed Original Research
2007
Risk of Malignancy in Resected Cystic Tumors of the Pancreas ≤3 cm in Size: Is it Safe to Observe Asymptomatic Patients? A Multi-institutional Report
Lee C, Scheiman J, Anderson M, Hines O, Reber H, Farrell J, Kochman M, Foley P, Drebin J, Oh Y, Ginsberg G, Ahmad N, Merchant N, Isbell J, Parikh A, Stokes J, Bauer T, Adams R, Simeone D. Risk of Malignancy in Resected Cystic Tumors of the Pancreas ≤3 cm in Size: Is it Safe to Observe Asymptomatic Patients? A Multi-institutional Report. Journal Of Gastrointestinal Surgery 2007, 12: 234-242. PMID: 18040749, DOI: 10.1007/s11605-007-0381-y.Peer-Reviewed Original ResearchConceptsCystic pancreatic tumorsPancreatic resectionFemale patientsCystic neoplasmsRadiographic featuresPancreatic tumorsRecent international consensus guidelinesHigh-volume pancreatic centersPancreatic resection databaseGroup of patientsInternational consensus guidelinesPresence of malignancyPrevalence of malignancyMagnetic resonance imagingAsymptomatic patientsMale patientsPancreatic centersConsensus guidelinesPathological dataMalignant pathologyEndoscopic ultrasoundHigh incidencePatientsMalignancyGreater incidence
2000
GASTROINTESTINAL BLEEDING IN OLDER PEOPLE
Farrell J, Friedman L. GASTROINTESTINAL BLEEDING IN OLDER PEOPLE. Gastroenterology Clinics Of North America 2000, 29: 1-36. PMID: 10752016, DOI: 10.1016/s0889-8553(05)70106-0.Peer-Reviewed Original ResearchConceptsGastrointestinal bleedingOlder peopleGreater medication useLower gastrointestinal bleedingAtypical clinical presentationCommon clinical challengeRates of comorbidityHemodynamic resuscitationSurgical therapyMedication useClinical presentationCommon causeClinical challengeBleedingAnticoagulationImportant management issuesComorbiditiesResuscitationTherapy