Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning
Weiss R, Dufour S, Taksali SE, Tamborlane WV, Petersen KF, Bonadonna RC, Boselli L, Barbetta G, Allen K, Rife F, Savoye M, Dziura J, Sherwin R, Shulman GI, Caprio S. Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning. The Lancet 2003, 362: 951-957. PMID: 14511928, PMCID: PMC2995523, DOI: 10.1016/s0140-6736(03)14364-4.Peer-Reviewed Original ResearchConceptsImpaired glucose toleranceNormal glucose toleranceGlucose toleranceObese childrenInsulin resistanceObese adolescentsGlucose disposalInsulin sensitivitySevere peripheral insulin resistanceNon-oxidative glucose metabolismSubcutaneous fatH plasma glucose concentrationsAbdominal fat partitioningVisceral lipid contentsPeripheral glucose disposalHigher intramyocellular lipid contentAbdominal fat distributionDegree of obesityIntramyocellular lipid contentPeripheral insulin resistanceHigh visceral fatAbdominal subcutaneous fatEuglycaemic hyperinsulinaemic clampSevere insulin resistancePlasma glucose concentration