Apolipoprotein C3 Gene Variants in Nonalcoholic Fatty Liver Disease
Petersen KF, Dufour S, Hariri A, Nelson-Williams C, Foo JN, Zhang XM, Dziura J, Lifton RP, Shulman GI. Apolipoprotein C3 Gene Variants in Nonalcoholic Fatty Liver Disease. New England Journal Of Medicine 2010, 362: 1082-1089. PMID: 20335584, PMCID: PMC2976042, DOI: 10.1056/nejmoa0907295.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseFatty liver diseasePlasma triglyceride clearanceLiver diseaseFat tolerance testPlasma triglyceride concentrationsInsulin resistanceApolipoprotein C3Wild-type homozygotesIndian menTriglyceride clearanceTriglyceride concentrationsC3 concentrationsTriglyceride contentApolipoprotein C3 gene variantsHealthy Asian Indian menOral fat tolerance testType 2 diabetes mellitusVariant allelesIntravenous fat tolerance testLiver triglyceride contentHepatic triglyceride contentSingle nucleotide polymorphismsVariant allele carriersHepatic insulin resistance