2023
Selected-Lesion SRS as a Novel Strategy in Treatment of Patients with Multiple Brain Metastases
Singh C, Theriault B, An Y, Yu J, Knisely J, Shepard M, Wegner R, Warnick R, Peker S, Samanci Y, Trifiletti D, Lee C, Yang H, Bernstein K, Kondziolka D, Tripathi M, Mathieu D, Mantziaris G, Pikis S, Sheehan J, Chiang V. Selected-Lesion SRS as a Novel Strategy in Treatment of Patients with Multiple Brain Metastases. International Journal Of Radiation Oncology • Biology • Physics 2023, 117: e150-e151. DOI: 10.1016/j.ijrobp.2023.06.971.Peer-Reviewed Original ResearchWhole-brain radiation therapyTreatment of patientsSystemic diseaseBrain metastasesLesion locationIntracranial lesionsPrior whole-brain radiation therapyMultiple brain metastasesBrain radiation therapyUntreated brain metastasesBrain metastasis treatmentCurrent practice patternsSigns/symptomsPresence of symptomsMATERIAL/METHODSImmunotherapy optionsSystemic therapyUntreated lesionsMedical oncologyPerilesional edemaDrug optionsClinical trialsPractice patternsClinical indicationsMetastasis treatmentSelected-Lesion Stereotactic Radiosurgery (SL-SRS) as a Novel Strategy in the Treatment of Patients With Multiple Brain Metastases
Theriault B, Singh C, Yu J, Knisely J, Shepard M, Wegner R, Warnick R, Peker S, Samanci Y, Trifiletti D, Lee C, Yang H, Bernstein K, Kondziolka D, Tripathi M, Mathieu D, Mantziaris G, Pikis S, Sheehan J, Chiang V. Selected-Lesion Stereotactic Radiosurgery (SL-SRS) as a Novel Strategy in the Treatment of Patients With Multiple Brain Metastases. Cureus 2023, 15: e45457. PMID: 37859877, PMCID: PMC10583225, DOI: 10.7759/cureus.45457.Peer-Reviewed Original ResearchWhole brain radiotherapyInternational Radiosurgery Research FoundationPrior whole brain radiotherapyBrain metastasesStereotactic radiosurgeryCommon reasonAsymptomatic brain metastasesNon-eloquent locationsSystemic treatment optionsMultiple brain metastasesPoor functional statusTreatment of patientsCentral nervous systemAttributable symptomsExtracranial diseaseSystemic therapyUntreated lesionsMedical oncologySystemic diseaseFunctional statusTreatment optionsClinical trialsSingle lesionLesion locationIntracranial lesions
2022
Health Economics Research in Cancer Treatment: Current Challenges and Future Directions
Yu J, Schrag D, Yabroff K. Health Economics Research in Cancer Treatment: Current Challenges and Future Directions. JNCI Monographs 2022, 2022: 51-56. PMID: 35788370, DOI: 10.1093/jncimonographs/lgac009.Peer-Reviewed Original ResearchConceptsHealth economics researchMeasures of social determinants of healthCancer health economics researchNational Cancer Institute's Division of Cancer Control and Population SciencesSocial determinants of healthCost of cancer careDivision of Cancer Control and Population SciencesDeterminants of healthHealth-care systemStudies of cancer treatmentCancer treatmentCancer careIntegration of economic analysisInsurance typeHealth economistsPopulation scienceProspective economic studyHealthArea of focusWorkgroupStandard evaluationEconomic researchCancerCareClinical trials
2021
A reply to “Randomized controlled clinical trial is needed for toxicity of IMRT VS 3D-CRT in PORT for LA-NSCLC”
Jairam V, Soulos PR, Gross CP, Yu JB, Park HS, Decker RH. A reply to “Randomized controlled clinical trial is needed for toxicity of IMRT VS 3D-CRT in PORT for LA-NSCLC”. Lung Cancer 2021, 168: 84-85. PMID: 34933760, DOI: 10.1016/j.lungcan.2021.12.003.Peer-Reviewed Case Reports and Technical NotesSystematic review and meta-analysis of radiation therapy for high-risk non-muscle invasive bladder cancer
Rodrigues Pessoa R, Mueller A, Boxley P, Flaig T, Piper C, Konety B, Yu J, Gershman B, Kukreja J, Kim S. Systematic review and meta-analysis of radiation therapy for high-risk non-muscle invasive bladder cancer. Urologic Oncology Seminars And Original Investigations 2021, 39: 786.e1-786.e8. PMID: 33846085, DOI: 10.1016/j.urolonc.2021.03.009.Peer-Reviewed Original ResearchConceptsHigh-risk non-muscle invasive bladder cancerNon-muscle invasive bladder cancerCancer specific-survivalRecurrence-free survivalInvasive bladder cancerBacillus Calmette-GuerinOverall survivalRadiation therapyBladder cancerMeta-analysisRates of recurrence-free survivalClinical trialsGoal of bladder preservationMetastatic disease rateSalvage radical cystectomyCochrane Central Register of Controlled TrialsProspective clinical trialCentral Register of Controlled TrialsTreatment of patientsRegister of Controlled TrialsSystematic reviewCochrane Central RegisterLow-quality evidenceQuality of evidenceBladder preservation
2019
Results of a pilot/phase II study of gamma knife radiosurgery for brain metastases and implications for future prospective clinical trials
Yu J, Singh C, Bindra R, Contessa J, Husain Z, Hansen J, Park H, Roberts K, Bond J, Tien C, Guo F, Colaco R, Housri N, Magnuson W, Mahajan A, Omay S, Chiang V. Results of a pilot/phase II study of gamma knife radiosurgery for brain metastases and implications for future prospective clinical trials. Journal Of Radiation Oncology 2019, 8: 39-46. DOI: 10.1007/s13566-018-0370-7.Peer-Reviewed Original ResearchYale-New Haven HospitalPhase II studyBrain metastasesClinical trialsII studyKnife radiosurgeryLocal controlPre-defined primary endpointWhole-brain radiation treatmentFuture prospective clinical trialsEvaluable brain metastasesSymptomatic radiation necrosisMedian patient ageLocal control ratePhase 2 studyGood local controlProspective clinical trialsNumber of metastasesLarge clinical trialsProportional hazards regressionFuture clinical trialsGamma knife radiosurgeryImportant clinical variablesStandard clinical practiceNew Haven Hospital
2016
Digital health application for real-time patient-reported outcomes during prostate radiotherapy.
Yang D, Thea J, An Y, Yu J. Digital health application for real-time patient-reported outcomes during prostate radiotherapy. Journal Of Clinical Oncology 2016, 34: 157-157. DOI: 10.1200/jco.2016.34.2_suppl.157.Peer-Reviewed Original ResearchPatient-reported outcomesQuality of lifeProstate radiotherapyTreatment periodExpanded Prostate Index CompositeClinical practice surveyDaily radiation treatmentsGenitourinary Cancers SymposiumFuture prospective studiesProstate cancer patientsClinical trial dataPatient Data CollectionPaucity of dataClinical research toolCancer SymposiumRoutine followPatient reportingProspective studySingle institutionCancer patientsClinical trialsSide effectsQOL domainsPatientsTrial data
2014
Considerations for Observational Research Using Large Data Sets in Radiation Oncology
Jagsi R, Bekelman J, Chen A, Chen R, Hoffman K, Shih Y, Smith B, Yu J. Considerations for Observational Research Using Large Data Sets in Radiation Oncology. International Journal Of Radiation Oncology • Biology • Physics 2014, 90: 11-24. PMID: 25195986, PMCID: PMC4159773, DOI: 10.1016/j.ijrobp.2014.05.013.Peer-Reviewed Original ResearchMeSH KeywordsChecklistComparative Effectiveness ResearchDatabases, FactualDiffusion of InnovationHealth Care CostsHealth Services ResearchHealth SurveysInsurance Claim ReviewMedicareNeoplasmsNomogramsObservational Studies as TopicProfessional PracticePropensity ScorePublication BiasRadiation OncologyRare DiseasesRegistriesResearch DesignSEER ProgramUnited StatesConceptsRadiation oncology communityRadiation oncologyObservational researchHealth services researchObservational studyWell-designed observational studiesOncology communityField of radiation oncologyHealth careServices researchEvaluate causalityObservational analysisData sourcesInternational Journal of Radiation OncologyMethodological expertiseRadiation oncology researchEvaluate evidenceRecognition of limitationsOncologyClinical trialsPotential data sourcesResearch questionsOncology researchHealthMethodological considerations
2012
An Assessment of the Collective Efforts of Clinical Trials to Provide Evidence-based Practice Guidelines in Cancer Care
Lloyd S, Buscariollo D, Gross C, Makarov D, Yu J. An Assessment of the Collective Efforts of Clinical Trials to Provide Evidence-based Practice Guidelines in Cancer Care. International Journal Of Radiation Oncology • Biology • Physics 2012, 84: s43-s44. DOI: 10.1016/j.ijrobp.2012.07.325.Peer-Reviewed Original ResearchAn assessment of the collective efforts of clinical trials to provide evidence-based practice guidelines in cancer care.
Lloyd S, Buscariollo D, Gross C, Makarov D, Yu J. An assessment of the collective efforts of clinical trials to provide evidence-based practice guidelines in cancer care. Journal Of Clinical Oncology 2012, 30: 6019-6019. DOI: 10.1200/jco.2012.30.15_suppl.6019.Peer-Reviewed Original ResearchRCT enrollmentMeasures of burdenCancer research effortsNCCN guidelinesNCCN recommendationsEndometrial cancerNational Comprehensive Cancer Network guidelinesEvidence-based practice guidelinesPhase 3 RCTsClinical trial enrollmentPrevalent solid tumorsTrial enrollmentNetwork guidelinesCancer careCNS cancerTreatment recommendationsClinical trialsProstate cancerPractice guidelinesSolid tumorsLife yearsMultivariate analysisMost recommendationsCancer typesCancer
2011
Are the Efforts of Current Clinical Trials Involving Radiation Therapy Focused on the Evidence Gaps in Cancer Treatment?
Lloyd S, Gross C, Makarov D, Yu J. Are the Efforts of Current Clinical Trials Involving Radiation Therapy Focused on the Evidence Gaps in Cancer Treatment? International Journal Of Radiation Oncology • Biology • Physics 2011, 81: s139-s140. DOI: 10.1016/j.ijrobp.2011.06.286.Peer-Reviewed Original Research