2018
Oxytocin attenuates trust as a subset of more general reinforcement learning, with altered reward circuit functional connectivity in males
Ide J, Nedic S, Wong K, Strey S, Lawson E, Dickerson B, Wald L, La Camera G, Mujica-Parodi L. Oxytocin attenuates trust as a subset of more general reinforcement learning, with altered reward circuit functional connectivity in males. NeuroImage 2018, 174: 35-43. PMID: 29486321, DOI: 10.1016/j.neuroimage.2018.02.035.Peer-Reviewed Original ResearchConceptsUltra-high field fMRIPre-existing beliefsReinforcement learningBrain encodingGeneral reinforcement learningNeuroeconomic taskIntranasal oxytocinFace of informationField fMRIFeedback learningFMRI activationExperimental paradigmNegative rewardsOrbitofrontal cortexSocial learningReward circuitBehavioral trajectoriesFunctional connectivityConnectivity analysisSocial contextSubjects' behaviorSocial relationshipsBehavioral effectsLearningBayesian expectation
2016
Abnormal reward circuitry in anorexia nervosa: A longitudinal, multimodal MRI study
Cha J, Ide J, Bowman F, Simpson H, Posner J, Steinglass J. Abnormal reward circuitry in anorexia nervosa: A longitudinal, multimodal MRI study. Human Brain Mapping 2016, 37: 3835-3846. PMID: 27273474, PMCID: PMC5448464, DOI: 10.1002/hbm.23279.Peer-Reviewed Original ResearchConceptsAnorexia nervosaWeight restorationResting-state functional MRI scansStructural connectivityInpatient weight restorationFunctional MRI scansHum Brain MappUnderweight phaseUnderweight stateWhite matter anisotropyHealthy controlsUnderweight individualsFemale inpatientsAltered connectionsMRI scansFunctional connectivityDisorder symptomsEffective connectivityIllnessReward processingEffect sizeSame timeframeInpatientsPathophysiologySymptoms