2012
Transcriptional repression of RUNX2 is associated with aggressive clinicopathological outcomes, whereas nuclear location of the protein is related to metastasis in prostate cancer
Yun S, Yoon H, Bae S, Lee O, Choi Y, Moon S, Kim I, Kim W. Transcriptional repression of RUNX2 is associated with aggressive clinicopathological outcomes, whereas nuclear location of the protein is related to metastasis in prostate cancer. Prostate Cancer And Prostatic Diseases 2012, 15: 369-373. PMID: 22890388, DOI: 10.1038/pcan.2012.31.Peer-Reviewed Original ResearchConceptsMetastatic diseaseGleason scoreProstate cancerMRNA expressionElevated PSA levelsNon-metastatic diseaseCase-control studyLow Gleason scoreRunx2 expressionHuman prostate tissuePSA levelsBPH patientsClinicopathological characteristicsClinicopathological outcomesCommon cancerLower PSAPrognostic markerReal-time PCRImmunohistochemical stainingImmunohistochemical analysisTranscription factor 2BPH controlProstate tissueRunx2 mRNA expressionCaP aggressiveness
2002
The Human Papilloma Virus E7 Oncoprotein Inhibits Transforming Growth Factor-β Signaling by Blocking Binding of the Smad Complex to Its Target Sequence*
Lee D, Kim B, Kim I, Cho E, Satterwhite D, Kim S. The Human Papilloma Virus E7 Oncoprotein Inhibits Transforming Growth Factor-β Signaling by Blocking Binding of the Smad Complex to Its Target Sequence*. Journal Of Biological Chemistry 2002, 277: 38557-38564. PMID: 12145312, DOI: 10.1074/jbc.m206786200.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCyclin-Dependent KinasesDNADNA-Binding ProteinsFemaleGenes, ReporterHumansOncogene Proteins, ViralPapillomaviridaeProtein BindingSignal TransductionSmad ProteinsTrans-ActivatorsTranscription, GeneticTransforming Growth Factor betaTransforming Growth Factor beta1Uterine Cervical NeoplasmsConceptsHuman papillomavirus (HPV) oncoprotein E7HPV-positive cellsCervical cancerTGF-beta signalingSuppression of SmadConfocal microscopic studiesE7 oncoproteinsOncoprotein E7Growth inhibitory activitySmad transcriptional activityHPVE7Inhibitory activityMicroscopic studyTranscriptional activityDNA synthesisSmadSmad proteinsSignalingEtiologyCancerInfectionPRB
1997
Prostatic ductal system in rats: Tissue‐specific expression and regional variation in stromal distribution of transforming growth factor‐β1
Nemeth J, Sensibar J, White R, Zelner D, Kim I, Lee C. Prostatic ductal system in rats: Tissue‐specific expression and regional variation in stromal distribution of transforming growth factor‐β1. The Prostate 1997, 33: 64-71. PMID: 9294629, DOI: 10.1002/(sici)1097-0045(19970915)33:1<64::aid-pros11>3.0.co;2-j.Peer-Reviewed Original ResearchConceptsProstatic ductal systemDuctal systemRat ventral prostateAlpha-smooth muscle actin-positive stromal cellsVentral prostateProstatic smooth muscleGrowth factor-β1Stromal-epithelial interactionsEpithelial cell deathNormal rat prostateCell deathEpithelial cell compartmentStromal cell fractionImmunohistochemical stainingSmooth muscleStromal distributionFactor-β1Rat prostateGrowth regulatory roleNormal prostateProximal ductPercoll gradient centrifugationProstateStromal cellsRT-PCR analysis