2019
Urinary Cell-Free DNA IQGAP3/BMP4 Ratio as a Prognostic Marker for Non–Muscle-Invasive Bladder Cancer
Xu Y, Kim Y, Jeong P, Piao X, Byun Y, Seo S, Kang H, Kim W, Lee J, Ryu D, Choi J, Kim I, Moon S, Choi Y, Yun S, Kim W. Urinary Cell-Free DNA IQGAP3/BMP4 Ratio as a Prognostic Marker for Non–Muscle-Invasive Bladder Cancer. Clinical Genitourinary Cancer 2019, 17: e704-e711. PMID: 31088707, DOI: 10.1016/j.clgc.2019.04.001.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBiomarkers, TumorBone Morphogenetic Protein 4Cell-Free Nucleic AcidsDisease ProgressionFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGenes, Tumor SuppressorGTPase-Activating ProteinsHumansMaleMiddle AgedNuclear ProteinsPrognosisSurvival AnalysisUrinary Bladder NeoplasmsConceptsProgression-free survivalCox regression analysisRecurrence-free survivalDisease recurrenceBladder cancerNon-muscle invasive bladder cancerInvasive bladder cancer patientsWorse progression-free survivalMultivariate Cox regression analysisWorse recurrence-free survivalKaplan-Meier analysisKaplan-Meier curvesBladder cancer patientsRegression analysisUrinary cell-free DNAValuable novel biomarkersCell-free DNANMIBC patientsClinical outcomesCancer patientsDisease progressionPrognostic markerReal-time PCRNovel biomarkersIndependent factors
2013
HOXA9, ISL1 and ALDH1A3 methylation patterns as prognostic markers for nonmuscle invasive bladder cancer: Array‐based DNA methylation and expression profiling
Kim Y, Yoon H, Kim J, Kang H, Min B, Kim S, Ha Y, Kim I, Ryu K, Lee S, Kim W. HOXA9, ISL1 and ALDH1A3 methylation patterns as prognostic markers for nonmuscle invasive bladder cancer: Array‐based DNA methylation and expression profiling. International Journal Of Cancer 2013, 133: 1135-1142. PMID: 23436614, DOI: 10.1002/ijc.28121.Peer-Reviewed Original ResearchConceptsISL LIM homeobox 1Novel methylation markersDNA methylationNonmuscle invasive bladder cancerMethylation patternsHomeobox A9DNA methylation patternsInvasive bladder cancerDecreased gene expression levelsLIM homeobox 1RNA expression patternsGene expression profilesAldehyde dehydrogenase 1 familyGene expression levelsMethylation markersNMIBC patientsDisease recurrenceBladder cancerExpression profilingExpression patternsExpression profilesMicroarray analysisNormal controlsPyrosequencing analysisHomeobox 1
2012
RUNX3 methylation in normal surrounding urothelium of patients with non-muscle-invasive bladder cancer: Potential role in the prediction of tumor progression
Jeong P, Min B, Ha Y, Song P, Kim I, Ryu K, Kim J, Yun S, Kim W. RUNX3 methylation in normal surrounding urothelium of patients with non-muscle-invasive bladder cancer: Potential role in the prediction of tumor progression. European Journal Of Surgical Oncology 2012, 38: 1095-1100. PMID: 22884471, DOI: 10.1016/j.ejso.2012.07.116.Peer-Reviewed Original ResearchConceptsNon-muscle invasive bladder cancerNormal adjacent urotheliumInvasive bladder cancerTransurethral resectionNormal urotheliumAdjacent urotheliumRUNX3 methylationRUNX3 promoter methylationNMIBC patientsBladder cancerTumor tissueMultivariate Cox regression analysisUrothelium of patientsCox regression analysisKaplan-Meier estimatesPromoter methylationBladder tumor developmentNormal adjacent tissuesMethylation-specific polymerase chain reactionIndependent predictorsTumor numberPolymerase chain reactionPatientsSignificant associationTumor progression