Featured Publications
Cost-Effectiveness of Aspirin for Extended Venous Thromboembolism Prophylaxis After Major Surgery for Inflammatory Bowel Disease
Leeds IL, Sklow B, Gorgun E, Liska D, Lightner AL, Hull TL, Steele SR, Holubar SD. Cost-Effectiveness of Aspirin for Extended Venous Thromboembolism Prophylaxis After Major Surgery for Inflammatory Bowel Disease. Journal Of Gastrointestinal Surgery 2022, 26: 1275-1285. PMID: 35277799, DOI: 10.1007/s11605-022-05287-z.Peer-Reviewed Original ResearchMeSH KeywordsAftercareAnticoagulantsAspirinCost-Benefit AnalysisEnoxaparinHumansInflammatory Bowel DiseasesPatient DischargeVenous ThromboembolismConceptsInflammatory bowel disease surgeryLow-dose aspirinQuality-adjusted life yearsThromboembolism prophylaxisDisease surgeryUnfavorable incremental cost-effectiveness ratiosLife yearsExtended venous thromboembolism prophylaxisPost-discharge event ratePocket costsIncremental cost-effectiveness ratioVenous thromboembolism prophylaxisEfficacy of aspirinInflammatory bowel diseaseMedian hospital costsMonte Carlo probabilistic sensitivity analysisCost-effectiveness ratioProbabilistic sensitivity analysesDecision analysis modelEnoxaparin regimenThromboembolism ratesVenous thromboembolismBowel diseaseColorectal surgeryCase patients
2022
Do Cost Limitations of Extended Prophylaxis After Surgery Apply to Ulcerative Colitis Patients?
Leeds IL, Canner JK, DiBrito SR, Safar B. Do Cost Limitations of Extended Prophylaxis After Surgery Apply to Ulcerative Colitis Patients? Diseases Of The Colon & Rectum 2022, 65: 702-712. PMID: 34840290, PMCID: PMC8995329, DOI: 10.1097/dcr.0000000000002056.Peer-Reviewed Original ResearchMeSH KeywordsColitis, UlcerativeColorectal SurgeryHumansPostoperative ComplicationsQuality-Adjusted Life YearsRetrospective StudiesVenous ThromboembolismConceptsMultivariable probabilistic sensitivity analysesUlcerative colitis patientsIncremental cost-effectiveness ratioProbabilistic sensitivity analysesCost-effectiveness ratioDecision analysisColorectal surgery patientsExtended prophylaxisColitis patientsEl análisisSocietal perspectiveLifetime horizonSurgery patientsVenous thromboembolismColitis ulcerosaDecision analysis methodologyUn análisisPostoperative venous thromboembolismRange of scenariosType of thrombosisMain outcome measuresTotal costIndividual risk profileCostSensitivity analysis
2019
Are We Really Supposed to Start Giving Venous Thromboembolism Prophylaxis for a Month After Outpatient Surgery?
Leeds IL, Haut ER. Are We Really Supposed to Start Giving Venous Thromboembolism Prophylaxis for a Month After Outpatient Surgery? JAMA Surgery 2019, 154: 1133-1133. PMID: 31596432, DOI: 10.1001/jamasurg.2019.3753.Peer-Reviewed Original ResearchCost-Benefit Limitations of Extended, Outpatient Venous Thromboembolism Prophylaxis Following Surgery for Crohn's Disease.
Leeds IL, DiBrito SR, Canner JK, Haut ER, Safar B. Cost-Benefit Limitations of Extended, Outpatient Venous Thromboembolism Prophylaxis Following Surgery for Crohn's Disease. Diseases Of The Colon & Rectum 2019, 62: 1371-1380. PMID: 31596763, PMCID: PMC6788772, DOI: 10.1097/dcr.0000000000001461.Peer-Reviewed Original ResearchConceptsVenous thromboembolism prophylaxisMultivariable probabilistic sensitivity analysesCrohn's diseaseHigh thrombotic riskProbabilistic sensitivity analysesThromboembolism prophylaxisExtended prophylaxisSurgical populationAbdominal surgeryThrombotic eventsUtility weightsSocietal perspectiveProductivity costsLifetime horizonIncremental costConventional measuresEnfermedad de CrohnPostoperative venous thromboembolismLow absolute riskHigh-risk individualsLos costosDecision tree modelDecision analysisRange of scenariosTotal costJustifying Total Costs of Extended Venothromboembolism Prophylaxis After Colorectal Cancer Surgery
Leeds IL, Canner JK, DiBrito SR, Safar B. Justifying Total Costs of Extended Venothromboembolism Prophylaxis After Colorectal Cancer Surgery. Journal Of Gastrointestinal Surgery 2019, 24: 677-687. PMID: 30945086, PMCID: PMC6776724, DOI: 10.1007/s11605-019-04206-z.Peer-Reviewed Original ResearchMeSH KeywordsAnticoagulantsColorectal NeoplasmsCost-Benefit AnalysisHemorrhageHumansQuality-Adjusted Life YearsVenous ThromboembolismConceptsVTE event ratesColorectal cancer surgeryCancer surgeryDecision analysis modelEvent ratesCancer surgical patientsHigher VTE ratesHigh-risk patientsCase fatality ratePayer administrative databaseOutcomes of interestProbabilistic sensitivity analysesBackgroundCurrent guidelinesBleeding eventsExtended prophylaxisProvider uptakeVTE ratesVTE eventsMost patientsPostoperative dischargeSurgical patientsRisk stratificationAdministrative databasesClinical guidanceNational guidelines