Whole Genome Sequencing Reveals Novel Recurring Somatic Mutations Affecting HUWE1 and DIAPH2 Genes in Multiple Myeloma
Tomasson M, Shen D, Hucthagowder V, Schierding W, Mullins C, Fiala M, Hall I, Wallis J, Fulton R, Fulton L, Kulkarni S, Mardis E, Wilson R, Ley T, DiPersio J, Maher C, Vij R, Ding L. Whole Genome Sequencing Reveals Novel Recurring Somatic Mutations Affecting HUWE1 and DIAPH2 Genes in Multiple Myeloma. Blood 2012, 120: 320. DOI: 10.1182/blood.v120.21.320.320.Peer-Reviewed Original ResearchMultiple myelomaMM patientsPeripheral bloodNormal controlsB cellsTumor cellsImportant clinical correlationsWhole-genome sequencingAbnormal B cellsSingle nucleotide variantsSodium-activated potassium channelsCommon driver mutationsPlasma B cellsChromosomal translocationsMalignant cell populationNon-hyperdiploid multiple myelomaIncurable malignancyClinical correlationWG casesPatientsEarly genetic eventsDisease pathogenesisNovel translocationDriver mutationsPotassium channels