Inmaculada Ruz-Maldonado
Associate Research ScientistCards
About
Research
Publications
2026
Impaired glycosylation promotes rapid transition to hepatocellular carcinoma in model of diet induced steatotic liver disease
Singh A, Chaube B, Citrin K, Fowler J, Lee S, Catarino J, Knight J, Lowery S, Shree S, Mahoney K, Boutagy N, Ruz-Maldonado I, Harry K, Shanabrough M, Ross T, Malaker S, Suárez Y, Fernández-Hernando C, Grabińska K, Sessa W. Impaired glycosylation promotes rapid transition to hepatocellular carcinoma in model of diet induced steatotic liver disease. Journal Of Clinical Investigation 2026, 136: e197719. PMID: 41805633, PMCID: PMC13132402, DOI: 10.1172/jci197719.Peer-Reviewed Original Research
2024
Global deletion of G protein‐coupled receptor 55 impairs glucose homeostasis during obesity by reducing insulin secretion and β‐cell turnover
Liu B, Ruz‐Maldonado I, Persaud S. Global deletion of G protein‐coupled receptor 55 impairs glucose homeostasis during obesity by reducing insulin secretion and β‐cell turnover. Diabetes Obesity And Metabolism 2024, 26: 4591-4601. PMID: 39113250, DOI: 10.1111/dom.15816.Peer-Reviewed Original ResearchFatty acid binding protein 5 suppression attenuates obesity-induced hepatocellular carcinoma by promoting ferroptosis and intratumoral immune rewiring
Sun J, Esplugues E, Bort A, Cardelo M, Ruz-Maldonado I, Fernández-Tussy P, Wong C, Wang H, Ojima I, Kaczocha M, Perry R, Suárez Y, Fernández-Hernando C. Fatty acid binding protein 5 suppression attenuates obesity-induced hepatocellular carcinoma by promoting ferroptosis and intratumoral immune rewiring. Nature Metabolism 2024, 6: 741-763. PMID: 38664583, PMCID: PMC12355809, DOI: 10.1038/s42255-024-01019-6.Peer-Reviewed Original ResearchHeterogeneity of hepatocyte dynamics restores liver architecture after chemical, physical or viral damage
Ruz-Maldonado I, Gonzalez J, Zhang H, Sun J, Bort A, Kabir I, Kibbey R, Suárez Y, Greif D, Fernández-Hernando C. Heterogeneity of hepatocyte dynamics restores liver architecture after chemical, physical or viral damage. Nature Communications 2024, 15: 1247. PMID: 38341404, PMCID: PMC10858916, DOI: 10.1038/s41467-024-45439-0.Peer-Reviewed Original Research
2023
Kisspeptin upregulates β-cell serotonin production during pregnancy
Hill T, Smith L, Ruz-Maldonado I, Jones P, Bowe J. Kisspeptin upregulates β-cell serotonin production during pregnancy. Journal Of Endocrinology 2023, 260: e230218. PMID: 37997938, PMCID: PMC10762540, DOI: 10.1530/joe-23-0218.Peer-Reviewed Original Research
2016
The diet‐derived short chain fatty acid propionate improves beta‐cell function in humans and stimulates insulin secretion from human islets in vitro
Pingitore A, Chambers E, Hill T, Maldonado I, Liu B, Bewick G, Morrison D, Preston T, Wallis G, Tedford C, González R, Huang G, Choudhary P, Frost G, Persaud S. The diet‐derived short chain fatty acid propionate improves beta‐cell function in humans and stimulates insulin secretion from human islets in vitro. Diabetes Obesity And Metabolism 2016, 19: 257-265. PMID: 27761989, DOI: 10.1111/dom.12811.Peer-Reviewed Original ResearchAdultAgedApoptosisBlotting, WesternCaspase 3Caspase 7ColonDietary FatsEstersFatty Acids, NonesterifiedFatty Acids, VolatileFemaleGlucagon-Like Peptide 1HumansImmunohistochemistryIn Vitro TechniquesInsulinInsulin SecretionInsulin-Secreting CellsInulinIslets of LangerhansMaleMiddle AgedPropionatesReceptors, Cell Surface