2020
Initial posaconazole dosing to achieve therapeutic serum posaconazole concentrations among children, adolescents, and young adults receiving delayed‐release tablet and intravenous posaconazole
Bernardo V, Miles A, Fernandez AJ, Liverman R, Tippett A, Yildirim I. Initial posaconazole dosing to achieve therapeutic serum posaconazole concentrations among children, adolescents, and young adults receiving delayed‐release tablet and intravenous posaconazole. Pediatric Transplantation 2020, 24: e13777. PMID: 32639095, DOI: 10.1111/petr.13777.Peer-Reviewed Original ResearchConceptsYears of ageMedian daily doseTrough concentrationsDaily dosePlasma concentrationsYoung adultsPlasma trough concentrationsSerum posaconazole concentrationsInvasive fungal diseaseTherapeutic plasma concentrationsDelayed-release tabletsIntravenous posaconazolePosaconazole dosingImmunocompromised childrenPatients 13Optimal dosingBroad-spectrum antifungalsAdolescent patientsPosaconazole concentrationsHigher dosingPatientsBody weightGrade 1ProphylaxisDosing
2007
Role of Procalcitonin and CRP in Differentiating a Stable From a Deteriorating Clinical Course in Pediatric Febrile Neutropenia
Secmeer G, Devrim I, Kara A, Ceyhan M, Cengiz B, Kutluk T, Buyukpamukcu M, Yetgin S, Tuncer M, Uludag AK, Tezer H, Yildirim I. Role of Procalcitonin and CRP in Differentiating a Stable From a Deteriorating Clinical Course in Pediatric Febrile Neutropenia. Journal Of Pediatric Hematology/Oncology 2007, 29: 107-111. PMID: 17279007, DOI: 10.1097/mph.0b013e3180320b5b.Peer-Reviewed Original ResearchConceptsNeutropenic fever patientsC-reactive proteinIntensive chemotherapyNeutropenic feverPCT concentrationsErythrocyte sedimentation rate levelsHacettepe University Ihsan Doğramaci Children's HospitalHours of onsetRole of procalcitoninValue of procalcitoninErythrocyte sedimentation ratePediatric febrile neutropeniaFebrile neutropeniaInflammation parametersControl patientsCRP levelsFebrile episodesOccult infectionUnderlying diseaseAntibiotic therapyClinical courseChildren's HospitalProspective studyTherapy modificationLeukocyte count