2021
A Retrospective Test-Negative Case-Control Study to Evaluate Influenza Vaccine Effectiveness in Preventing Hospitalizations in Children
Yildirim I, Kao CM, Tippett A, Suntarattiwong P, Munye M, Yi J, Elmontser M, Quincer E, Focht C, Watson N, Bilen H, Baker JM, Lopman B, Hogenesch E, Rostad CA, Anderson EJ. A Retrospective Test-Negative Case-Control Study to Evaluate Influenza Vaccine Effectiveness in Preventing Hospitalizations in Children. Clinical Infectious Diseases 2021, 73: 1759-1767. PMID: 34410341, PMCID: PMC8599178, DOI: 10.1093/cid/ciab709.Peer-Reviewed Original ResearchConceptsInfluenza vaccine effectivenessInfluenza-positive casesInfluenza-related hospitalizationsVaccine effectivenessInfluenza seasonOdds ratioInfluenza ALaboratory-confirmed influenza-related hospitalizationsTest-negative case-control study designAdjusted vaccine effectivenessInfluenza-negative controlsTest-negative controlsCase-control study designHospitalization of childrenTest-negative casesConfidence intervalsNon-Hispanic blacksLogistic regression modelsPreventing HospitalizationInfluenza vaccinationInfluenza burdenMedian ageInfluenza B.Influenza infectionPediatric hospitalizations
2020
The burden of respiratory syncytial virus infections among children with sickle cell disease
Rostad CA, Maillis AN, Lai K, Bakshi N, Jerris RC, Lane PA, Yee ME, Yildirim I. The burden of respiratory syncytial virus infections among children with sickle cell disease. Pediatric Blood & Cancer 2020, 68: e28759. PMID: 33034160, PMCID: PMC8246443, DOI: 10.1002/pbc.28759.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusSickle cell diseaseRespiratory viral panelRSV-positive casesRSV infectionAnnual incidenceHospitalization ratesCell diseaseBurden of RSVPediatric lower respiratory tract infectionsLaboratory-confirmed RSV infectionRespiratory syncytial virus infectionRSV-related hospitalization rateLower respiratory tract infectionsRSV positive testRSV-negative childrenRSV-negative patientsAcute chest syndromeSyncytial virus infectionRespiratory tract infectionsAverage annual incidenceMultivariate logistic regressionConfidence intervalsCase-control studyOutcome of childrenUrinary Tract Infections With Extended-spectrum-β-lactamase-producing Bacteria: Case-control Study.
Amin O, Prestel C, Gonzalez MD, Lyon T, Shane A, Jaggi P, Tippett A, Yildirim I. Urinary Tract Infections With Extended-spectrum-β-lactamase-producing Bacteria: Case-control Study. The Pediatric Infectious Disease Journal 2020, 39: 211-216. PMID: 32032306, DOI: 10.1097/inf.0000000000002531.Peer-Reviewed Original ResearchConceptsUrinary tract infectionESBL-producing bacteriaCase-control studyRisk factorsTract infectionsPrior intensive care unit admissionIntensive care unit admissionPediatric urinary tract infectionCause of UTIClinical signs/symptomsCare unit admissionIndependent risk factorYear of diagnosisΒ-lactamase-producing bacteriaSigns/symptomsCommon bacterial infectionsSpectrum β-lactamasesRational antimicrobial useESBL casesESBL-UTIUnit admissionUnderlying comorbiditiesPrior hospitalizationEmpirical therapyPediatric patients
2019
Assessment and Validation of Syndromic Case Definitions for Respiratory Syncytial Virus Infections in Young Infants: A Latent Class Analysis.
Lalani K, Yildirim I, Phadke VK, Bednarczyk RA, Omer SB. Assessment and Validation of Syndromic Case Definitions for Respiratory Syncytial Virus Infections in Young Infants: A Latent Class Analysis. The Pediatric Infectious Disease Journal 2019, 38: 1177-1182. PMID: 31568250, DOI: 10.1097/inf.0000000000002468.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusSyndromic case definitionsCase definitionYoung infantsWorld Health OrganizationRSV infectionLatent class analysisPredictive valueLaboratory-confirmed RSV infectionRespiratory syncytial virus infectionSyncytial virus infectionAcute respiratory infectionsHigh positive predictive valueRoutine clinical careStandardized case definitionsHigh-resource settingsAppropriate case definitionsHigh-income settingsNegative predictive valueMonths of agePositive predictive valueRespiratory infectionsVaccine evaluationClinical featuresPediatric morbidityHospitalization Is an Underutilized Opportunity to Vaccinate for Influenza
Anderson EJ, Kao C, Yildirim I. Hospitalization Is an Underutilized Opportunity to Vaccinate for Influenza. Mayo Clinic Proceedings 2019, 94: 377-379. PMID: 30832785, DOI: 10.1016/j.mayocp.2019.01.012.Peer-Reviewed Original Research
2009
Multicenter Prospective Study on the Burden of Rotavirus Gastroenteritis in Turkey, 2005–2006: A Hospital-Based Study
Ceyhan M, Alhan E, Salman N, Kurugol Z, Yildirim I, Celik U, Keser M, Koturoglu G, Tezer H, Bulbul EK, Karabocuoglu M, Halicioglu O, Anis S, Pawinski R. Multicenter Prospective Study on the Burden of Rotavirus Gastroenteritis in Turkey, 2005–2006: A Hospital-Based Study. The Journal Of Infectious Diseases 2009, 200: s234-s238. PMID: 19817603, DOI: 10.1086/605056.Peer-Reviewed Original ResearchConceptsRotavirus gastroenteritisWorld Health Organization's generic protocolRotavirus-positive childrenPrevalence of rotavirusMulticenter prospective studyRotavirus vaccineProspective surveillanceProspective studyDisease burdenMortality rateGastroenteritisPrevalent strainsRotavirusIndividual centersChildrenBurdenMain causeHospitalizationHospitalInfantsVaccineYearsPrevalence