Featured Publications
Vibrational optical coherence tomography detects unique skin fibrotic states: Preliminary results of animal and human studies
Odell ID, Flavell RA, Silver FH. Vibrational optical coherence tomography detects unique skin fibrotic states: Preliminary results of animal and human studies. Journal Of The American Academy Of Dermatology 2020, 85: 780-782. PMID: 32860914, PMCID: PMC9793292, DOI: 10.1016/j.jaad.2020.08.091.Peer-Reviewed Original ResearchEpiregulin is a dendritic cell–derived EGFR ligand that maintains skin and lung fibrosis
Odell I, Steach H, Gauld S, Reinke-Breen L, Karman J, Carr T, Wetter J, Phillips L, Hinchcliff M, Flavell R. Epiregulin is a dendritic cell–derived EGFR ligand that maintains skin and lung fibrosis. Science Immunology 2022, 7: eabq6691. PMID: 36490328, PMCID: PMC9840167, DOI: 10.1126/sciimmunol.abq6691.Peer-Reviewed Original ResearchConceptsLung fibrosisDendritic cellsImmune cellsDiffuse cutaneous systemic sclerosisPersistence of fibrosisCutaneous systemic sclerosisExtent of fibrosisType I interferonSystemic sclerosisAutoimmune diseasesAntifibrotic targetsTherapeutic administrationMouse modelI interferonLung samplesLung explantsFibrosisFibrotic tissueImmune signalsEpiregulin expressionPatient's skinExtracellular matrix productionGenetic deficiencyEpiregulinEGFR ligands
2023
IL-6 trans-signaling in a humanized mouse model of scleroderma
Odell I, Agrawal K, Sefik E, Odell A, Caves E, Kirkiles-Smith N, Horsley V, Hinchcliff M, Pober J, Kluger Y, Flavell R. IL-6 trans-signaling in a humanized mouse model of scleroderma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2306965120. PMID: 37669366, PMCID: PMC10500188, DOI: 10.1073/pnas.2306965120.Peer-Reviewed Original ResearchConceptsBone marrow-derived immune cellsIL-6Human hematopoietic stem cellsImmune cellsT cellsScleroderma skinSoluble IL-6 receptorCD8 T cellsHumanized mouse modelPathogenesis of sclerodermaMesenchymal cellsFibroblast-derived IL-6IL-6 receptorIL-6 signalingT cell activationHuman IL-6Human T cellsExpression of collagenFibrosis improvementPansclerotic morpheaHuman endothelial cellsHumanized miceReduced markersSkin graftsHuman CD4
2019
HER2 joins AKT to inhibit STING immunity
Odell ID, Flavell RA. HER2 joins AKT to inhibit STING immunity. Nature Cell Biology 2019, 21: 917-918. PMID: 31371829, DOI: 10.1038/s41556-019-0368-4.Peer-Reviewed Original Research
2012
Rules of engagement for base excision repair in chromatin
Odell ID, Wallace SS, Pederson DS. Rules of engagement for base excision repair in chromatin. Journal Of Cellular Physiology 2012, 228: 258-266. PMID: 22718094, PMCID: PMC3468691, DOI: 10.1002/jcp.24134.Peer-Reviewed Original ResearchConceptsBase excision repairSingle-strand break repairNucleotide excision repairHomology-directed repairExcision repairCheckpoint activationCell cycle checkpoint activationStrand break repair pathwaysDouble-strand break repair pathwayStrand break repairBreak repair pathwayOxidative damage resultsNucleosome disruptionDNA replicationBreak repairRepair pathwaysDNA segmentsChromatinEfficient repairNumerous DNAOxidative DNA damageRegulatory factorsHuman cellsNucleosomesDNA damage
2011
Nucleosome Disruption by DNA Ligase III-XRCC1 Promotes Efficient Base Excision Repair
Odell ID, Barbour JE, Murphy DL, Della-Maria JA, Sweasy JB, Tomkinson AE, Wallace SS, Pederson DS. Nucleosome Disruption by DNA Ligase III-XRCC1 Promotes Efficient Base Excision Repair. Molecular And Cellular Biology 2011, 31: 4623-4632. PMID: 21930793, PMCID: PMC3209256, DOI: 10.1128/mcb.05715-11.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDeoxyribonuclease (Pyrimidine Dimer)DNADNA DamageDNA GlycosylasesDNA Ligase ATPDNA LigasesDNA Polymerase betaDNA RepairDNA-(Apurinic or Apyrimidinic Site) LyaseDNA-Binding ProteinsHumansLytechinusNucleosomesPoly-ADP-Ribose Binding ProteinsReactive Oxygen SpeciesXenopusXenopus ProteinsX-ray Repair Cross Complementing Protein 1ConceptsBase excision repairNucleosome disruptionApurinic endonucleaseExcision repairEfficient base excision repairNucleated human cellsDNA polymerase βNucleosome substratesRibosomal DNASingle base gapHuman cellsNucleosomesDNA ligasePolymerase βPol βRate-limiting stepHNTH1Ternary complexDNAUnique roleChromatinLigaseDisruptionEndonucleaseLesions form
2005
A systematic RNAi screen for longevity genes in C. elegans
Hamilton B, Dong Y, Shindo M, Liu W, Odell I, Ruvkun G, Lee SS. A systematic RNAi screen for longevity genes in C. elegans. Genes & Development 2005, 19: 1544-1555. PMID: 15998808, PMCID: PMC1172061, DOI: 10.1101/gad.1308205.Peer-Reviewed Original ResearchConceptsLongevity genesGenome-wide functional genomics screenDAF-16/FOXO transcription factorRNA interferenceDAF-16/FOXONew longevity genesSystematic RNAi screenFunctional genomic screensFOXO transcription factorsLarge-scale RNA interferenceCandidate longevity genesRNAi inactivationAnimal phylogenyRNAi screenC. elegansGenetic interactionsGenomic screenSignal transductionTranscription factorsDaf-2Gene expressionProtein deacetylaseProtein turnoverGenesPathway