2016
Gender-specific differences in PPARγ regulation of follicular helper T cell responses with estrogen
Park HJ, Park HS, Lee JU, Bothwell AL, Choi JM. Gender-specific differences in PPARγ regulation of follicular helper T cell responses with estrogen. Scientific Reports 2016, 6: 28495. PMID: 27335315, PMCID: PMC4917844, DOI: 10.1038/srep28495.Peer-Reviewed Original ResearchConceptsFollicular helper T cell responsesHelper T cell responsesT cell responsesCell responsesTfh cellsT cellsGC responseMale T cellsPeroxisome proliferator-activated receptor gammaTfh cell responsesEffector T cellsPPARγ agonist pioglitazoneProliferator-activated receptor gammaT cell regulationWild-type miceRole of PPARγGerminal center B cellsT cell activationGender-specific differencesTfh responsesAgonist pioglitazoneAutoimmune diseasesMenstrual cycleFemale miceMale mice
2015
PPARγ controls effector T cell functions to prevent autoimmunity in gender different way (BA4P.135)
Park H, Kim D, Kim W, Choi J. PPARγ controls effector T cell functions to prevent autoimmunity in gender different way (BA4P.135). The Journal Of Immunology 2015, 194: 47.15-47.15. DOI: 10.4049/jimmunol.194.supp.47.15.Peer-Reviewed Original ResearchT cell functionT cellsPeroxisome proliferator-activated receptor gammaTh17 cellsEstrogen receptorEffector T cell functionFollicular helper T cellsHelper T cellsAuto-antibody productionExpression of Bcl-2T cell differentiationProliferator-activated receptor gammaMild autoimmune phenotypeIL-7RAPrevent autoimmunityPioglitazone treatmentGerminal centersMale miceTCR stimulationAdaptive immunityAutoimmune phenotypeDecreased expressionBcl-2MiceMouse phenotype