2015
Piceatannol inhibits effector T cell functions by suppressing TcR signaling
Kim D, Lee Y, Park H, Lee J, Kim H, Hwang J, Choi J. Piceatannol inhibits effector T cell functions by suppressing TcR signaling. International Immunopharmacology 2015, 25: 285-292. PMID: 25676533, DOI: 10.1016/j.intimp.2015.01.030.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAntigens, Differentiation, T-LymphocyteCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell DifferentiationCytokinesFemaleInterleukin-2 Receptor alpha SubunitLectins, C-TypeMice, Inbred C57BLMitogen-Activated Protein KinasesPhosphorylationProtein Kinase InhibitorsReceptors, Antigen, T-CellSpleenStilbenesConceptsEffector T cell functionT cell functionT cellsPiceatannol treatmentT cell activation markers CD25Naïve CD4 T cellsRole of piceatannolCD4 T cellsActivation markers CD25Cell functionAdaptive immune responsesSplenic T cellsMetabolite of resveratrolMurine splenic T cellsInhibition of TCRActivated T cellsAnti-tumorigenesis activityT cell activationIL-17Th17 cellsCytokines IFNγC57BL/6 miceCytokine productionIL-2Immune response
2013
The nuclear receptor PPARγ regulates T cell tolerance and germinal center formation via generation of follicular helper T cells (P4545)
Choi J, Park H, Choi J, Senejani A, Tobiasova Z, Kim D, Bothwell A. The nuclear receptor PPARγ regulates T cell tolerance and germinal center formation via generation of follicular helper T cells (P4545). The Journal Of Immunology 2013, 190: 197.7-197.7. DOI: 10.4049/jimmunol.190.supp.197.7.Peer-Reviewed Original ResearchT cell toleranceFollicular helper T cellsHelper T cellsT cellsGerminal center formationDeficient T cellsCell toleranceHelper T cell subsetsExpression of IkBαPeroxisome proliferator-activated receptor gammaT cell subsetsProliferator-activated receptor gammaWild-type T cellsType T cellsRole of PPARγNuclear receptor PPARγFunction of PPARγPhosphorylation of ERKTfh generationTh9 cellsIL-17Kidney inflammationAutoantibody productionCell subsetsCenter formation